One-pot catalytic synthesis of 2,7-bis-substituted 4,9(10)-dimethyl-2,3a,5a,7,8a,10a-hexaazaperhydropyrenes

Article abstract of DOI:10.1016/j.tet.2017.10.048

Catalytic methods for the synthesis of 2,7-bis-substituted 4,9(10)-dimethyl-2,3a,5a,7,8a,10a-hexaazaperhydropyrenes have been developed. The structure was established on the basis of ¹H and ¹³C NMR spectra, 2D NMR (HSQC, HMBC, COSY, NOESY) techniques, MALDI TOF/TOF spectra, and X-ray diffraction data. Primary screening of the synthesized hexaazaperhydropyrenes for antimicrobial activity was performed.