Journal of Medicinal Chemistry p. 1068 - 1072 (1980)
Update date:2022-08-25
Topics:
Mechoulam, R.
Lander, N.
Varkony, T. H.
Kimmel, I.
Becker, O.
et al.
Several pairs of cannabinoid isomers were synthesized and tested for psychotropic activity in rhesus monkeys.Two regularities were observed: (a) In the absence of the other substituents, the equatorial stereochemistry of the substituent at C-1 determines activity. (b) Two groups of THC-type cannabinoids which differ only in that the chemical groupings in one of them at C-1, C-2 are situated at C-1, C-6 in the other (but retain their stereochemistry) have almost equivalent psychotropic activity.
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