Bioorganic and Medicinal Chemistry Letters p. 3419 - 3422 (1998)
Update date:2022-08-22
Topics:
Murali, Dhanabalan
DeJesus, Onofre T.
We have prepared 4'-epi-iodo-4'-deoxy-daunorubicin (IDDNR)(1), a doxorubicin analog, via a 5-step synthesis involving a protected daunorubicin triflate derivative (4). This triflate derivative will allow the facile and regiospecific nucleophilic preparation of I-125 or Br-80m labelled analogs of IDDNR. Auger electronemitting I-125- or Br-80m-labelled analogs of IDDNR may have potential as cancer radiotherapeutic agents.
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