Synthesis and structure–activity relationship study of novel 3-diethoxyphosphorylfuroquinoline-4,9-diones with potent antitumor efficacy

DOI: 10.1016/j.ejmech.2021.113429

Source and publish data:

European Journal of Medicinal Chemistry (2021)

Update date:2022-08-11

Topics:

Authors:

Modranka, Jakub

Drogosz-Stachowicz, Joanna

Pietrzak, Anna

Janecka, Anna

Janecki, Tomasz

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Article abstract of DOI:10.1016/j.ejmech.2021.113429

Herein we report an efficient synthesis of a series of regioisomeric N,O-syn and N,O-anti 3-diethoxyphosphorylfuroquinoline-4,9-diones combining furoquinoline-5,8-dione skeleton, present in several highly cytotoxic compounds, with diethoxyphosphoryl moiet

Full text of DOI:10.1016/j.ejmech.2021.113429

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