Synthesis and biological activities of indolactone-V, the lactone analogue of the tumor promoter (-)-indolactam-V.

Article abstract of DOI:10.1271/bbb.61.1415

The tumor promoter (-)-indolactam-V (1) exists in two stable conformers (twist and sofa) due to isomerization of the amide group. Indolactone-V (2), the lactone analogue of 1, has been synthesized to investigate the effects of the amide group on its conformation and biological activities. Indolactone-V (2) existed only as the inactive sofa-like conformer, indicating that the amide group of 1 plays a critical role in formation of the active twist conformation.

Full text of DOI:10.1271/bbb.61.1415

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Synthesis and Biological Activities of Indolactone-
V, the Lactone Analogue of the Tumor Promoter (–)-
Indolactam-V
ab
a
a
a
a
Yu Nakagawa , Kazuhiro Irie , Yoshimasa Nakamura , Hajime Ohigashi & Hideo Hayashi
a
Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University,
Sakyo-ku, Kyoto 606, Japan
b
Department of Applied Biochemistry, Faculty of Agriculture, University of Osaka
Prefecture, Sakai 593, Japan
Published online: 12 Jun 2014.
To cite this article: Yu Nakagawa, Kazuhiro Irie, Yoshimasa Nakamura, Hajime Ohigashi & Hideo Hayashi (1997) Synthesis
and Biological Activities of Indolactone-V, the Lactone Analogue of the Tumor Promoter (–)-Indolactam-V, Bioscience,
Biotechnology, and Biochemistry, 61:8, 1415-1417, DOI: 10.1271/bbb.61.1415
To link to this article: http://dx.doi.org/10.1271/bbb.61.1415
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