Synthesis of 4-functionalized indoles via benzyne cyclization of N-(2- lithioallyl)-2-fluoroanilines

DOI: 10.1016/S0040-4039(99)80109-9

Source and publish data:

Tetrahedron Letters p. 1049 - 1052 (1999)

Update date:2022-08-11

Topics:

Authors:

Barluenga, Jose

Fananas, Francisco J.

Sanz, Roberto

Fernandez, Yolanda

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(99)80109-9

Treatment of N-(2-bromoallyl)-N-methyl-2-fluoroaniline with tert- butyllithium affords 1,3-dimethyl-4-lithioindole, via intramolecular addition to a tethered benzyne intermediate. Further reaction with electrophiles leads to 4-functionalized 3-methylindol

Full text of DOI:10.1016/S0040-4039(99)80109-9

Products guided by the article

Product name:3-CHLORO-N-METHYLANILINE

Cas No:7006-52-2

R&D Labs maybe for 7006-52-2

Jiangxi Huashi Pharmaceutical Co., Ltd

Contact:+86-795-4509628

Address:Ningbo Ave., Fengtian Industrial Park, Fengxin Country, Jiangxi, China.
Shreeji pharma international

Contact:0091-265-2313036

Address:311, ATLANTIS HEIGHTS SARABHAI MAIN ROAD,VADIWADI ,VADODARA
Baoding City Light Industry And Textiles Imp.& Exp. Corp. Chemical Department.

Contact:86-312-3262436

Address:NO.658 CHAOYANG SOUTH STREET,BAODING CITY HEBEI CHINA
Ji'nan Orgachem Pharmaceutical Co.,Ltd

Contact:+86-531-82687810

Address:Jinan
henan victory industry co.ltd

Contact:86-371-63655023

Address:No.85,jinshui road,zhengzhou,China

Relevant to this article

A naphthalimide-rhodamine ratiometric fluorescent probe for Hg²⁺ based on fluorescence resonance energy transfer

Doi:10.1016/j.dyepig.2011.07.020
(2012)
Enhancing the bioconversion of azelaic acid to its derivatives by response surface methodology

Doi:10.3390/molecules23020397
(2018)
Selective sensing of Cr^VI and Fe^III ions in aqueous solution by an exceptionally stable Tb^III-organic framework with an AIE-active ligand

Doi:10.1016/j.cclet.2021.01.040
(2021)
Impact of the Long-Range Electronic Effect of a Fluorous Ponytail on Metal Coordination during Solvent Extraction

Doi:10.1002/cphc.201701030
(2017)
The phase transition of ZrP induced by Si in Al-Si melts

Doi:10.1016/j.jallcom.2012.03.025
(2012)
Catalytic conversion of dihydroxyacetone to lactic acid using metal salts in water

Doi:10.1002/cssc.201000457
(2011)

Article Doi