Different structures of the two peroxisome proliferator-activated receptor gamma (PPARγ) ligand-binding domains in homodimeric complex with partial agonist, but not full agonist

DOI: 10.1016/j.bmcl.2015.04.076

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Bioorganic and Medicinal Chemistry Letters p. 2639 - 2644 (2015)

Update date:2022-08-11

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Authors:

Ohashi, Masao

Oyama, Takuji

Miyachi, Hiroyuki

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Article abstract of DOI:10.1016/j.bmcl.2015.04.076

We designed and synthesized acylsulfonamide derivative (3) as a human peroxisome proliferator-activated receptor gamma (hPPARγ) partial agonist by structural modification of hPPARγ full agonist 1. Co-crystallization of 3 with hPPARγ LBD afforded a homodim

Full text of DOI:10.1016/j.bmcl.2015.04.076

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