Bromo-6-methoxy-8-aminoquinolines: Preparation and 13C-NMR assignments

Article abstract of DOI:10.1002/jps.2600731256

Preparation of all possible monobromo-6-methoxy-8-aminoquinolines is reported. These materials provided an opportunity to assess the effect of bromine substitution on ¹³C-NMR chemical shift patterns. An explanation of the isomerization of 5-bromo-6-methoxy-8-acetamidoquinoline to 7-bromo-6-methoxy-8-aminoquinoline during hydrolysis is presented.