A practical synthesis of N-acetyl-5-methoxy-tryptamine (melatonin)

Article abstract of DOI:10.1080/00397919908086203

The pineal hormone melatonin is conveniently prepared in simple one pot operation by treating 4-methoxyphenylhydrazine hydrochloride(6) with acetic anhydride and 4-aminobutyraldehyde dimethylacetal(4) in a mixed solvent system of acetic acid/ethanol/water.

Full text of DOI:10.1080/00397919908086203

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Synthetic Communications: An
International Journal for Rapid
Communication of Synthetic
Organic Chemistry
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A Practical Synthesis of N-
Acetyl-5-methoxy-tryptamine
(
Melatonin)
a
a
Ki-Jun Hwangyy & Tae-Suk Lee
a
Department of Chemistry, College of Natural
Science, Chonbuk National University, Dukjindong,
664-14, Korea
Version of record first published: 17 Sep 2007
To cite this article: Ki-Jun Hwangyy & Tae-Suk Lee (1999): A Practical Synthesis
of N-Acetyl-5-methoxy-tryptamine (Melatonin), Synthetic Communications: An
International Journal for Rapid Communication of Synthetic Organic Chemistry, 29:12,
2099-2104
To link to this article: http://dx.doi.org/10.1080/00397919908086203
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