Lignans from Piper cubeba

Article abstract of DOI:10.1016/S0031-9422(00)83546-3

From the hot petrol extract of Piper cubeba ftuits, six lignans were isolated. Two of these, which have been obtained from a natural source for the first time, have been characterized as (2R,3R)-2-(3″,4″,5″-trimethoxybenzyl)-3-(3′,4′-methylenedioxybenzyl)-1,4-butanediol [(-)-dihydroclusin] and (3R,4R)-3,4-bis-(3,4,5-trimethoxybenzyl)tetra-hydro-2-furanol [(-)-cubebinin]. (-)Cubebin, (-)-hinokinin, (-)-clusin and (-)-dihydrocubebin were also found in this plant. Only (-)-cubebin has been reported so far from this source.