R.M. Amin et al. / Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 95 (2012) 517–525
525
In general, the six Schiff bases had an antibacterial effect on
both E. coli and S. capitis, possibly due to the presence of azome-
thine groups (imines) which have chelating properties. These prop-
erties may affect the metal transport across the bacterial
membranes or bind the bacterial cells at specific site and thus in-
hibit their growth. This is in agreement with Huheey et al. who
mentioned that antibiotics such as streptomycin, aspergillic acid,
and tetracycline which had chelating properties were able to com-
pete successfully with metal-binding agents of bacteria and thus
interfering with their growth [30–32].
Schiff base derivatives in order to enhance their effect on bacterial
cells. As a next step, the sensitivity of eukaryotic cells to these
Schiff bases and their complexes should be examined.
Acknowledgement
This study was supported by the Bibliotheca Alexandrina,
Center for Special Studies and Programs.
References
Comparison between Schiff bases containing substituent OCH3
on position 5 (SB1,SB2 and SB3) and those containing hydroxy group
at the same position (SB4, SB5 and SB6) on both bacterial starins
were studied according to the order SB1 with SB4, SB2 with SB5
and SB3 with SB6 as shown in Fig. 5–7 respectively. Analysis of
the data of the growth curves showed that SB1 had higher antibac-
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