Preliminary synthetic studies of methyllycaconitine, a potent nicotinic acetylcholine receptor antagonist: Rapid syntheses of AE-Bicyclic analogues

Article abstract of DOI:10.1111/j.2042-7158.1996.tb07125.x

A series of bicyclic analogues incorporating the homocholine motif of methyllycaconitine has been prepared to test the hypothesis that this is the essential pharmacophore of this potent, selective nicotinic receptor antagonist. A double Mannich reaction h