Synthesis of H-3 labeled 5-fluoro-3-[3-[4-(5-methoxy-4-pyrimidinyl)-1- piperazinyl]propyl]-1H-indole, a serotonergic agent with potential antidepressant activity

Article abstract of DOI:10.1002/jlcr.2580360810

The title compound was prepared by the LiAlT₄ reduction of 5-fluoro-3-[3-[4-(5-methoxy-4-pyrimidinyl)-1-piperazinyl]- 3-oxopropyl]-1H-indole. The radiochemical purity of the product was 98.9% and the specific activity was calculated as 53.0 Ci/mmol from HPLC analyses and 55.6 Ci/mmol from ³H NMR measurements.