Dirami et al · Notch Pathway Components in Spermatogonia
951
Gray GE, Mann RS, Mitsiadis E, et al. Human ligands of the Notch
receptor. Am J Pathol. 1999;154:785–794.
cleaves Notch upon ligand binding (Wolfe et al, 1999) or
exert an indirect effect by mediating the transit of Notch
Hamada Y, Kadokawa Y, Okabe M, Ikawa M, Coleman JR, Tsujimoto Y.
Mutation in ankyrin repeats of the mouse Notch2 gene induces early
embryonic lethality. Development. 1999;126:3415–3424.
Hansson V, Calandra R, Purvis K, Ritzen M, French FS. Hormonal reg-
ulation of spermatogenesis. Vitam Horm. 1976;34:187–214.
Henrique D, Adam J, Myat A, Chitnis A, Lewis J, Ish-Horowicz D. Ex-
pression of a Delta homologue in prospective neurons in the chick.
Nature. 1995;375:787–790.
and
␥ secretase to an as-yet-undefined subcellular com-
partment where cleavage occurs (Seugnet et al, 1997).
Future studies focusing on the role of Notch signaling
in the fate of spermatogonial stem cells will pave the way
for understanding the process of spermatogenesis.
Hicks C, Johnston SH, diSibio G, Collazo A, Vogt TF, Weinmaster G.
Fringe differentially modulates Jagged1 and Delta1 signaling through
Notch1 and Notch2. Nat Cell Biol. 2000;2:515–520.
References
Arduengo PM, Appleberry OK, Chuang P, L’Hernault SW. The presenilin
protein family member SPE-4 localizes to an ER/Golgi derived or-
ganelle and is required for proper cytoplasmic partitioning during
Caenorhabditis elegans spermatogenesis. J Cell Sci. 1998;111:3645–
Kim TW, Pettingell WH, Hallmark OG, Moir RD, Wasco W, Tanzi RE.
Endoproteolytic cleavage and proteasomal degradation of presenilin
2 in transfected cells. J Biol Chem. 1997;272:11006–11010.
Lah JJ, Heilman CJ, Nash NR, Rees HD, Yi H, Counts SE, Levey AI.
Light and electron microscopic localization of presenilin-1 in primate
brain. J Neurosci. 1997;17:1971–1980.
Lardelli M, Dahlstrand J, Lendahl U. The novel Notch homologue mouse
Notch 3 lacks specific epidermal growth factor-repeats and is ex-
pressed in proliferating neuroepithelium. Mech Dev. 1994;46:123–
136.
3
654.
Artavanis-Tsakonas S, Matsuno K, Fortini ME. Notch signaling. Science.
995;268:225–232.
1
Artavanis-Tsakonas S, Rand MD, Lake RJ. Notch signaling: cell fate
control and signal integration in development. Science. 1999;284:
7
70–776.
Beatus P, Lundkvist J, Oberg C, Lendahl U. The notch 3 intracellular
domain represses notch 1-mediated activation through Hairy/Enhanc-
er of split (HES) promoters. Development. 1999;126:3925–3935.
Beckers J, Clark A, Wunsch K, Hrabe DA, Gossler A. Expression of the
mouse Delta 1 gene during organogenesis and fetal development.
Mech Dev. 1999;84:165–168.
Lee MK, Slunt HH, Martin LJ, et al. Expression of presenilin 1 and 2
(PS1 and PS2) in human and murine tissues. J Neurosci. 1996;16:
7513–7525.
Levitan D, Greenwald I. Effects of SEL-12 presenilin on LIN-12 locali-
zation and function in Caenorhabditis elegans. Development. 1998;
125:3599–3606.
Bishop SA, Klein T, Arias AM, Couso JP. Composite signaling from
Serrate and Delta establishes leg segments in Drosophila through
Notch. Development. 1999;126:2993–3003.
Blaumueller CM, Qi H, Zagouras P, Artavanis-Tsakonas S. Intracellular
cleavage of Notch leads to a heterodimeric receptor on the plasma
membrane. Cell. 1997;90:281–291.
Brou C, Logeat F, Gupta N, et al. A novel proteolytic cleavage involved
in Notch signaling: the role of the disintegrin-metalloprotease TACE.
Mol Cell. 2000;5:207–216.
Chaudhary J, Skinner MK. The basic helix-loop-helix E2A gene product
E47, not E12, is present in differentiating Sertoli cells. Mol Reprod
Dev. 1999;52:1–8.
Lindsell CE, Shawber CJ, Boulter J, Weinmaster G. Jagged: a mammalian
ligand that activates Notch1. Cell. 1995;80:909–917.
Logeat F, Bessia C, Brou C, LeBail O, Jarriault S, Seidah NG, Israel A.
The Notch1 receptor is cleaved constitutively by a furin-like conver-
tase. Proc Natl Acad Sci USA. 1998;95:8108–8112.
Mitsiadis TA, Fried K, Goridis C. Reactivation of Delta-Notch signaling
after injury: complementary expression patterns of ligand and receptor
in dental pulp. Exp Cell Res. 1999;246:312–318.
Mitsiadis TA, Henrique D, Thesleff I, Lendahl U. Mouse Serrate-1 (Jag-
ged-1): expression in the developing tooth is regulated by epithelial-
mesenchymal interactions and fibroblast growth factor-4. Develop-
ment. 1997;124:1473–1483.
Chitnis A, Henrique D, Lewis J, Ish-Horowicz D, Kintner C. Primary
neurogenesis in Xenopus embryos regulated by a homologue of the
Drosophila neurogenic gene Delta. Nature. 1995;375:761–766.
Crittenden SL, Troemel ER, Evans TC, Kimble J. GLP-1 is localized to
the mitotic region of the C. elegans germ line. Development. 1994;
Mitsiadis TA, Hirsinger E, Lendahl U, Goridis C. Delta-notch signaling
in odontogenesis: correlation with cytodifferentiation and evidence for
feedback regulation. Dev Biol. 1998;204:420–431.
Mitsiadis TA, Lardelli M, Lendahl U, Thesleff I. Expression of Notch 1,
2 and 3 is regulated by epithelial-mesenchymal interactions and re-
tinoic acid in the developing mouse tooth and associated with deter-
mination of ameloblast cell fate. J Cell Biol. 1995;130:407–418.
Nakai T, Yamasaki A, Sakaguchi M, Kosaka K, Mihara K, Amaya Y,
Miura S. Membrane topology of Alzheimer’s disease-related presen-
ilin 1. Evidence for the existence of a molecular species with a seven
membrane-spanning and one membrane-embedded structure. J Biol
Chem. 1999;274:23647–23658.
Ordentlich P, Lin A, Shen CP, Blaumueller C, Matsuno K, Artavanis-
Tsakonas S, Kadesch T. Notch inhibition of E47 supports the exis-
tence of a novel signaling pathway. Mol Cell Biol. 1998;18:2230–
2239.
1
20:2901–2911.
Dirami G, Ravindranath N, Kleinman HK, Dym M. Evidence that base-
ment membrane prevents apoptosis of Sertoli cells in vitro in the
absence of known regulators of Sertoli cell function. Endocrinology.
1
995;136:4439–4447.
Dym M, Jia MC, Dirami G, Price JM, Rabin SJ, Mocchetti I, Ravin-
dranath N. Expression of c-kit receptor and its autophosphorylation
in immature rat type A spermatogonia. Biol Reprod. 1995;52:8–19.
Egan SE, St Pierre B, Leow CC. Notch receptors, partners and regulators:
from conserved domains to powerful functions. Curr Top Microbiol
Immunol. 1998;228:273–324.
Fehon RG, Kooh PJ, Rebay I, Regan CL, Xu T, Muskavitch MA, Arta-
vanis-Tsakonas S. Molecular interactions between the protein prod-
ucts of the neurogenic loci Notch and Delta, two EGF-homologous
genes in Drosophila. Cell 1990;61:523–534.
Go MJ, Eastman DS, Artavanis-Tsakonas S. Cell proliferation control by
Notch signaling in Drosophila development. Development. 1998;125:
Qi H, Rand MD, Wu X, Sestan N, Wang W, Rakic P, Xu T, Artavanis-
Tsakonas S. Processing of the notch ligand delta by the metallopro-
tease Kuzbanian. Science. 1999;283:91–94.
Ray WJ, Yao M, Nowotny P, Mumm J, Zhang W, Wu JY, Kopan R,
Goate AM. Evidence for a physical interaction between presenilin and
Notch. Proc Natl Acad Sci USA. 1999;96:3263–3268.
2
031–2040.
Russell LD, Ettlin RA, Sinha Hikim AP, Clegg ED. Mammalian Sper-