Synthesis of butanoic acid 4,4'-[(4E, 6Z, 9Z-pentadecatrien-2-ynylidene)]-bis with leukotriene-like activity: Novel acetylenic acetals and dithioacetals as antagonists of leukotriene-C4

DOI: 10.1016/S0040-4039(00)99018-X

Source and publish data:

Tetrahedron Letters p. 6427 - 6430 (1985)

Update date:2022-08-16

Topics:

Authors:

Saksena Saksena

Green Green

Mangiaracina

et al. et al.

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Article abstract of DOI:10.1016/S0040-4039(00)99018-X

A selective exchange reaction of a symmetrical acetal with protected cysteine readily provided two hemi-thioacetals related to leukotriene-E₄. Use of acetylene-bis-(diethyl acetal) led to a facile synthesis of the title compound. Its correspond

Full text of DOI:10.1016/S0040-4039(00)99018-X

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