Synthesis of 3-hydroxy-5-per(poly)fluoroalkyl pyrazoles

Article abstract of DOI:10.1016/0022-1139(95)03292-L

Treatment of ethyl α-per(poly)fluoroalkyl acetates 1 or ethyl α-iodo-β-per(poly)fluoroalkyl acrylates 2 with hydrazine gives 3-hydroxy-5-per(poly)fluoroalkyl pyrazoles 3 in excellent yield.The effect of halogens on the per(poly)fluoroalkyl chain and the reaction conditions were studied. - Keywords: Synthesis; Hydroxyper(poly)fluoroalkyl pyroles; NMR spectroscopy; IR spectroscopy; Mass spectrometry