Synthesis of 1-azabicyclo[3.3.0]octane derivatives and their effects as piracetam-like nootropics

DOI: 10.1248/cpb.48.1121

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Chemical and Pharmaceutical Bulletin p. 1121 - 1124 (2000)

Update date:2022-08-30

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Authors:

Oka Oka

Matsumoto

Hirooka Hirooka

Suzuki Suzuki

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Article abstract of DOI:10.1248/cpb.48.1121

A useful pharmaceutical intermediate, 5-nitromethyl-1-azabicyclo[3.3.0]octane (1), was prepared in one step from 1,7-dichloro-4-heptanone (4) under mild conditions. Catalytic hydrogenation of 1 over Raney Ni in the presence of sodium hydroxide afforded 5-

Full text of DOI:10.1248/cpb.48.1121

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