Heterocycles p. 3065 - 3069 (1986)
Update date:2022-08-10
Topics:
Somei, Masanori
Iwasa, Etsuo
Yamada, Fumio
4-Hydroxy-3-indolecarbaldehyde (1) is produced simply by heating (3-formylindol-4-yl)thallium bis-trifluoroacetate with copper sulfate in N,N-dimethylformamide and water.Alkylation of 1 afforded predominantly 1-alkyl derivatives.Utilizing these results pindolol analog, 1-allyl-4-(3-t-butylamino-2-hydroxypropoxy)-3-indolecarbaldehyde was synthesized.
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