Synthesis and in Vivo Antitumor Activity of Potential 5-Fluorouracil Prodrugs

DOI: 10.1021/jm00351a006

Source and publish data:

Journal of Medicinal Chemistry p. 1034 - 1040 (1982)

Update date:2022-08-12

Topics:

Authors:

Rosowsky, A.

Kim, S.-H.

Trites, D.

Wick, M.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00351a006

Analogues of 5'-deoxy-5-fluorouridine (DFUR, 1) were synthesized with the aim of evaluating the effect of structural modification of the 5' region of the ribofuranose moiety on the activity of these potential prodrug derivatives of 5-fluorouracil (FU).Rea

Full text of DOI:10.1021/jm00351a006

Products guided by the article

Product name:5-fluoro-2',3'-O-isopropylidene-5'-O-(p-toluenesulfonyl)uridine

Cas No:82276-89-9

R&D Labs maybe for 82276-89-9

XZL BIO-TECHNOLOGY CO., LTD.

Contact:0086 533 2282832

Address:Zibo，Shandong
Shanghai chemrole co.,ltd

Contact:021-50278900

Address:No.6,Room 201 ,Lane 299,bisheng road ,shanghai ,china
Zouping Mingxing Chemical Co.,Ltd.

website:http://www.zoutong.com.cn

Contact:86-543-2240068 2240067

Address:428 Daixi Third Road Zouping County Shandong Province China
SHANGHAI SYSTEAM BIOCHEM CO., LTD

website:http://www.systeambc.com

Contact:86-021-58380978

Address:Building 87，Lane 669， Dong Jing Road Shanghai,P.R.China
Jiangsu Feymer Technology Co., Ltd.

Contact:+86-512-58110132

Address:Fenghuang Town, Zhangjiagang City, Jiangsu Province, China

Relevant to this article

Two new coumarin derivatives from the roots of Heracleum rapula

Doi:10.1055/s-2004-827164
(2004)
Directing Group-Assisted Copper(II)-Catalyzed ortho-Carbonylation to Benzamide using 2,2′-Azobisisobutyronitrile (AIBN)

Doi:10.1002/adsc.201600664
(2016)
Doi:10.1016/S0022-328X(00)93125-5
(1974)
Unprecedented Nucleophilic Attack of Piperidine on the Electron Acceptor during the Synthesis of Push-Pull Dyes by a Knoevenagel Reaction

Doi:10.1002/hlca.201900229
(2019)
Synthesis of Donor/Acceptor-Substituted Diazo Compounds in Flow and Their Application in Enantioselective Dirhodium-Catalyzed Cyclopropanation and C-H Functionalization

Doi:10.1021/acs.orglett.7b01073
(2017)
Highly uniform supramolecular nano-films derived from carbazole-containing perylene diimide: Via surface-supported self-assembly and their electrically bistable memory behavior

Doi:10.1039/c8nj01380b
(2018)

Article Doi