UTILISATION DU FLUORURE DE TETRABUTYLAMMONIUM COMME AGENT DE CYCLISATION DANS LA SYNTHESE D'ANTIBACTERIENS DERIVES D'ACIDE PYRIDONE-4-CARBOXYLIQUE-3

Article abstract of DOI:10.1016/S0040-4039(00)82082-1

It has been found that the Bu4NF/THF base/solvent couple is very efficient in the key cyclization step of (2) to (5) in the synthesis of antibacterial pyridonecarboxylic acid derivatives.In particular chiral intermediate (2d) is directly converted in one