Synthesis of sterically high demanding α-alkylated amino acids via Claisen rearrangement of chelated enolates

Article abstract of DOI:10.1016/0040-4020(95)00946-9

Ester enolate Claisen rearrangement of chelated N-protected amino acid allylic esters 1 and 4 results in the formation of α-alkylated γ,δ-unsaturated amino acids 3 and 5 in good yields and in a highly diastereoselective fashion.