Synthesis of sterically high demanding α-alkylated amino acids via Claisen rearrangement of chelated enolates

DOI: 10.1016/0040-4020(95)00946-9

Source and publish data:

Tetrahedron p. 941 - 954 (1996)

Update date:2022-08-23

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Authors:

Kazmaier, Uli

Maier, Sabine

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Article abstract of DOI:10.1016/0040-4020(95)00946-9

Ester enolate Claisen rearrangement of chelated N-protected amino acid allylic esters 1 and 4 results in the formation of α-alkylated γ,δ-unsaturated amino acids 3 and 5 in good yields and in a highly diastereoselective fashion.

Full text of DOI:10.1016/0040-4020(95)00946-9

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