Bioorganic and Medicinal Chemistry Letters p. 811 - 816 (1998)
Update date:2022-08-17
Topics:
Tye, Ching-Kim
Kasinathan, Ganasan
Barrett, Michael P.
Brun, Reto
Doyle, Valerie E.
Fairlamb, Alan H.
Weaver, Richard
Gilbert, Ian H.
In this paper we describe an approach to selectively deliver compounds to trypanosomes using an adenosine transporter which is unique to the trypanosome. Various polyamine analogues have been attached to known substrates of this adenosine transporter. The compounds prepared interact specifically with the adenosine transporter, some with a similar efficiency to berenil, a known substrate.
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