Synthesis of new 3,4-disubstituted pyrrolidines as thromboxane A2/prostaglandin H2 (TP) receptor antagonists

Article abstract of DOI:10.1016/0960-894X(96)00021-2

The synthesis and TP-receptor antagonistic activity of a series of 3,4-disubstituted pyrrolidines is described. The sulfonamide 1h was the most potent TP-receptor antagonist in this series with a pA₂ value of 9.5 in isolated guinea pig trachea.