Synthesis of new 3,4-disubstituted pyrrolidines as thromboxane A2/prostaglandin H2 (TP) receptor antagonists

DOI: 10.1016/0960-894X(96)00021-2

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 349 - 352 (1996)

Update date:2022-08-29

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Authors:

Dubuffet, Thierry

Muller, Olivier

Simonet, Serge S.

Descombes, Jean-Jacques

Laubie, Michel

Verbeuren, Tony J.

Lavielle, Gilbert

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Article abstract of DOI:10.1016/0960-894X(96)00021-2

The synthesis and TP-receptor antagonistic activity of a series of 3,4-disubstituted pyrrolidines is described. The sulfonamide 1h was the most potent TP-receptor antagonist in this series with a pA₂ value of 9.5 in isolated guinea pig trachea.

Full text of DOI:10.1016/0960-894X(96)00021-2

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