Tetrahedron p. 3983 - 3998 (1998)
Update date:2022-09-26
Topics:
Creswell, Mark W.
Bolton, Gary L.
Hodges, John C.
Meppen, Malte
Polymer-supported quench methodology has been used for parallel purification of combinatorial libraries of dihydropyridones and their derivatives. The dihydropyridone scaffold was assembled via a solution phase Lewis acid catalyzed, hetero-Diels-Alder reaction. Further modifications allow for the rapid generation of subsequent aminopiperidine and acylaminopiperidine libraries utilizing a library from library approach.
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