ANTHRAQUINONES AND NAPHTHOHYDROQUINONES FROM RUBIA CORDIFOLIA

Article abstract of DOI:10.1016/0031-9422(89)80365-6

Four naphthohydroquinones and their glycosides, and 11 anthraquinones and their glycosides were isolated from the dried roots of Rubia cardifolia var. pratensis.Six of them, dihydromollugin, 2-carbomethoxy-3-(3'-hydroxy)isopentyl-1,4-naphthohydroquinone 4-O-β-glucoside, 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone 3-O-β-glucoside, 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone 3-O-(3'-O-acetyl)-α-rhamnosyl(1 -> 2)-β-glucoside, 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone 3-O-(3',6'-diacetyl)-α-rhamnosyl(1 -> 2)-β-glucoside and 2-metyl-1,3,6-trihydroxy-9,10-anthraquinone-3-O-(4',6'-O-diacetyl)-α-rhamnosyl(1 -> 2)-β-glucoside, were isolated for the first time from a natural source.The structures were established by various chemical and spectroscopic methods.The chemotaxonomic significance of these findings is discussed briefly.Key Word Index - Rubia cordifolia; Rubiaceae; anthraquinone; anthraquinone glycoside; naphthohydroquinone; naphthohydroquinone glycoside; 13C NMR.