Antifungal Peroxide-Containing Acids from Two Caribbean Sponges

Article abstract of DOI:10.1021/ja00364a045

Plakinic acids A and B, two new antifungal peroxy acids isolated from a Caribbean sponge, where assigned structures by spectroscopic techniques and by chemical degradation of their methyl esters, which were more easily purified.One of the acids contains the peroxide function as part of a five-membered ring.Plakortic acid, a carboxylic acid corresponding to plakortin, a previously described methyl ester, was isolated from another sponge.While the acids are potent antimicrobial compounds, the methyl esters, including plakortin, are essentially inactive.