Tetrahedron Letters p. 6871 - 6874 (1993)
Update date:2022-08-31
Topics:
Evans, David A.
Calter, Michael A.
Studies directed toward the C17-C18 aldol bond construction in the macrolide antibiotic bafilomycin A1 are described.The effect of the β-substituent in the aldol reactions of α-unsubstituted enolates is documented for various model compounds.The stereoselectivity of this process is critically dependent on the C21 and C23 oxygen protecting groups.Application of this methodology to the synthesis of bafilomycin A1 is reported.
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