The design and synthesis of novel adenosine agonists

Article abstract of DOI:10.1016/0960-894X(96)00111-4

The 2R and 2S-endo isomers of N⁶-(5,6-epoxynorborn-2-yl)adenosine have been synthesised and shown to be potent agonists for the A₁ adenosine receptor. The 2S-endo isomer was equipotent to N⁶-cyclopentyladenosine and 10- to 12-fold more potent than the 2R-endo isomer.