Synthesis and structure-activity relationships of side-chain-substituted analogs of the allylamine antimycotic terbinafine lacking the central amino function

Article abstract of DOI:10.1021/jm00010a029

Terbinafine is a therapeutically used inhibitor of fungal squalene epoxidase that has prompted extensive derivatization programs for structure- activity relationship studies. In the present study, derivatives of terbinafine were synthesized that lack the