Synthesis of Methylcubane and Cyclopropylcubane. The Cubane-1,4-diyl Route

Article abstract of DOI:10.1021/jo00109a030

Details for preparation of 1,4-diiodocubane from cubane-1,4-dicarboxylic acid are given.The diiodide is used to generate cubane-1,4-diyl, a nonisolable intermediate.Additions to the diyl are shown to provide for the ready synthesis in good yield of methylcubane, 1,4-dimethylcubane, cyclopropylcubane, etc.