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Nitrilotriacetic acid

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Name

Nitrilotriacetic acid

EINECS 205-355-7
CAS No. 139-13-9 Density 1.61 g/cm3
PSA 115.14000 LogP -1.45780
Solubility Insoluble. <0.01 g/100 mL at 23 ºC Melting Point 246 ºC
Formula C6H9NO6 Boiling Point 498.2 ºC at 760 mmHg
Molecular Weight 191.141 Flash Point 255.1 ºC
Transport Information N/A Appearance white powder
Safety 26-45-36/37/39-53 Risk Codes 40-36/37/38-45-20/21/22
Molecular Structure Molecular Structure of 139-13-9 (Nitrilotriacetic acid) Hazard Symbols HarmfulXn,ToxicT
Synonyms

Aceticacid, nitrilotri- (8CI);Complexon I;N,N-Bis(carboxymethyl)glycine;NSC 2121;NTA;Nitrilo-2,2',2''-triacetic acid;Nitrilo-N,N,N-triacetic acid;Nitrilotris(methylenecarboxylic acid);Titriplex I;Tris(hydroxycarbonylmethyl)amine;Versene NTA acid;a,a',a''-Trimethylaminetricarboxylic acid;

Article Data 37

Nitrilotriacetic acid Synthetic route

79-11-8

chloroacetic acid

56-40-6

glycine

A

139-13-9

nitrilotriacetic acid

B

142-73-4

iminodiacetic acid

Conditions
ConditionsYield
With lithium hydroxide for 144h; Ambient temperature;A 12.5 g
B 39%
With lithium hydroxide for 6h; Ambient temperature;A 12.5 g
B 39%
50-00-0

formaldehyd

19522-69-1

N-butylethylenediamine

143-33-9

sodium cyanide

A

139-13-9

nitrilotriacetic acid

B

73264-08-1

N-[2-(bis-carboxymethyl-amino)-ethyl]-N-butyl-glycine

Conditions
ConditionsYield
With sodium hydroxide; tert-butyl alcohol
50-00-0

formaldehyd

151-50-8

potassium cyanide

139-13-9

nitrilotriacetic acid

Conditions
ConditionsYield
With ammonia; water
With water
50-00-0

formaldehyd

151-50-8

potassium cyanide

A

79-14-1

glycolic Acid

B

139-13-9

nitrilotriacetic acid

C

56-40-6

glycine

D

142-73-4

iminodiacetic acid

7327-60-8

nitrilotriacetonitrile

139-13-9

nitrilotriacetic acid

Conditions
ConditionsYield
With hydrogenchloride; water
With barium dihydroxide
19247-05-3

N,N-dicarboxymethyl hydrazine

139-13-9

nitrilotriacetic acid

Conditions
ConditionsYield
With sulfuric acid at 150℃;
79-11-8

chloroacetic acid

56-40-6

glycine

139-13-9

nitrilotriacetic acid

Conditions
ConditionsYield
With potassium hydroxide at 80℃;
79-11-8

chloroacetic acid

139-13-9

nitrilotriacetic acid

Conditions
ConditionsYield
With ammonia; water anschliessend mit NaCN und Formaldehyd;
With ammonia
With ammonia; zinc(II) chloride
With ammonia
50-00-0

formaldehyd

143-33-9

sodium cyanide

56-40-6

glycine

139-13-9

nitrilotriacetic acid

Conditions
ConditionsYield
With sodium hydroxide
64-69-7

Iodoacetic acid

56-40-6

glycine

139-13-9

nitrilotriacetic acid

Conditions
ConditionsYield
With potassium hydroxide at 80℃;

Nitrilotriacetic acid Chemical Properties

Molecular Structure:

Molecular Formula: C6H9NO6
Molecular Weight: 191.1388
IUPAC Name: 2-[Bis(carboxymethyl)amino]acetic acid
Synonyms of Aminotriacetic acid (CAS NO.139-13-9): 4-04-00-02441 (Beilstein Handbook Reference) ; AI3-52483 ; Acetic acid, nitrilotri- ; BRN 1710776 ; CCRIS 436 ; CHEL 300 ; Complexon I ; EINECS 205-355-7 ; Glycine, N,N-bis(carboxymethyl)- ; HSDB 2853 ; Hampshire NTA acid ; Komplexon I ; Kyselina nitrilotrioctova ; Kyselina nitrilotrioctova [Czech] ; N,N-Bis(carboxymethyl)glycine ; NCI-C02766 ; NSC 2121 ; NTA ; Nitrilo-2,2',2''-triacetic acid ; Nitrilotriacetic acid ; Nitrilotriessigsaeure ; Titriplex I ; Tri(carboxymethyl)amine ; Triglycine ; Triglycollamic acid ; Trilon A ; Versene NTA acid ; alpha,alpha',alpha''-Trimethylaminetricarboxylic acid
CAS NO: 139-13-9
Classification Code: Chelating agents ; Mutation data ; Tumor data
Melting point: 245 °C 
Index of Refraction: 1.557
Molar Refractivity: 38.26 cm3
Molar Volume: 118.7 cm3
Surface Tension: 86.4 dyne/cm
Density: 1.61 g/cm3
Flash Point: 255.1 °C
Enthalpy of Vaporization: 83.9 kJ/mol
Boiling Point: 498.2 °C at 760 mmHg
Vapour Pressure: 2.78E-11 mmHg at 25°C

Nitrilotriacetic acid Uses

 Aminotriacetic acid (CAS NO.139-13-9) is a very good fixing agent in the dye industry.And it is worked as , in the styrene production, stabilize the agent role and  the role of catalyst and complexing agents, etc in the production of polyurethane foam.

Nitrilotriacetic acid Production

 Aminotriacetic acid (CAS NO.139-13-9) can be produced by the reaction of chloroacetic acid and sodium hydroxide.And then amino Tri-sodium chloride reaction and acidification the product is finished.

Nitrilotriacetic acid Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 325mg/kg (325mg/kg)   CRC Critical Reviews in Toxicology. Vol. 20, Pg. 83, 1989.
mouse LD50 oral 3160mg/kg (3160mg/kg)   Progress Report for Contract No. NIH-NCI-E-C-72-3252, Submitted to the National Cancer Institute by Litton Bionetics, Inc. Vol. NCI-E-C-72-3252, Pg. 1973,
rat LD50 oral 1100mg/kg (1100mg/kg)   Angewandte Chemie, International Edition in English. Vol. 14, Pg. 94, 1975.

Nitrilotriacetic acid Consensus Reports

NTP 10th Report on Carcinogens. IARC Cancer Review: Group 2B IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 48 (1990),p. 181.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Sufficient Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 48 (1990),p. 181.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Human No Adequate Data IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 48 (1990),p. 181.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . NCI Carcinogenesis Bioassay (feed); Clear Evidence: mouse, rat NCITR*    National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-CG-TR-6 ,1977. . Reported in EPA TSCA Inventory. Community Right-To-Know List.

Nitrilotriacetic acid Safety Profile

Confirmed carcinogen with experimental carcinogenic and neoplastigenic data. Poison by intraperitoneal route. Moderately toxic by ingestion. When heated to decomposition it emits toxic fumes of NOx.
Safety Information of Aminotriacetic acid (CAS NO.139-13-9):
Hazard Codes: HarmfulXn,ToxicT
Risk Statements: 40-36/37/38-45-20/21/22 
R40: Limited evidence of a carcinogenic effect. 
R36/37/38: Irritating to eyes, respiratory system and skin. 
R45: May cause cancer. 
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 26-45-36/37/39-53 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) 
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection. 
S53: Avoid exposure - obtain special instructions before use.
RIDADR: 2811
WGK Germany: 2
RTECS: AJ0175000
F: 21
HazardClass: 8
PackingGroup: II
HS Code: 29224995

Nitrilotriacetic acid Specification

Stability and Reactivity of Aminotriacetic acid (CAS NO.139-13-9).
Chemical Stability: Stable under normal temperatures and pressures. 
Conditions to Avoid: Incompatible materials. 
Incompatibilities with Other Materials Metals, strong oxidizing agents, strong bases. 
Hazardous Decomposition Products Nitrogen oxides, carbon monoxide, carbon dioxide. 
Hazardous Polymerization Will not occur. 
First Aid Measures of Aminotriacetic acid (CAS NO.139-13-9).
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.  Ingestion: Get medical aid. Wash mouth out with water. 
Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. 
Notes to Physician: Treat symptomatically and supportively. 
Handling and Storage of Aminotriacetic acid (CAS NO.139-13-9).
Handling: Do not breathe dust, vapor, mist, or gas. Do not get in eyes, on skin, or on clothing. Use only in a chemical fume hood. 
Storage: Store in a cool, dry place. Store in a tightly closed container. 

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