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Cas Database |
| Name |
Phenetidine |
EINECS | 205-855-5 |
| CAS No. | 156-43-4 | Density | 1.037 g/cm3 |
| PSA | 35.25000 | LogP | 2.24870 |
| Solubility | practically insoluble in water | Melting Point |
2-5 °C(lit.) |
| Formula | C8H11NO | Boiling Point | 254 °C at 760 mmHg |
| Molecular Weight | 137.181 | Flash Point | 110.3 °C |
| Transport Information | UN 2311 | Appearance | colourless liquid |
| Safety | 28-36/37-45-46 | Risk Codes | 23/24/25-33-68-43-36-20/21/22 |
| Molecular Structure |
|
Hazard Symbols |
 T, Xi, Xn
|
| Synonyms |
p-Phenetidine(8CI);1-Amino-4-ethoxybenzene;4-Aminophenetole;4-Ethoxyaniline;4-Ethoxybenzenamine;4-Ethoxyphenylamine;4-Phenetidine;NSC 3116;p-Aminophenetole;p-Ethoxyaniline;p-Ethoxyphenylamine;p-Phenetidin; |
Article Data | 148 |
Phenetidine Synthetic route
| Conditions | Yield |
|---|---|
| With hydrogen In 2-methyltetrahydrofuran; water at 40℃; under 15001.5 Torr; for 24h; chemoselective reaction; | 99% |
| With sodium sulfide; tetrabutylammomium bromide In water; toluene at 80℃; for 0.75h; Zinin reduction; | 98.4% |
| With hydrogen; triethylamine In ethanol; water at 110℃; under 30003 Torr; for 24h; Autoclave; | 96% |
- 4792-83-0, 51437-64-0
4,4'-diethoxyazoxybenzene
- 156-43-4
4-Ethoxyaniline
| Conditions | Yield |
|---|---|
| With N-doped TiO2 In methanol at 20℃; for 3h; UV-irradiation; Inert atmosphere; | 99% |
| Conditions | Yield |
|---|---|
| With sodium hydroxide; dimethyl sulfoxide | 90.1% |
- 103861-73-0
N-allyl-p-phenetidine
- 156-43-4
4-Ethoxyaniline
| Conditions | Yield |
|---|---|
| With polymethylhydrosiloxane; zinc(II) chloride; tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran at 20℃; | 88% |
| Conditions | Yield |
|---|---|
| With hemicucurbituril supported [Bmim]Cl In toluene for 10h; Reflux; | 80% |
| Conditions | Yield |
|---|---|
| With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 24h; | 78% |
| With sodium hydride In acetonitrile at 20℃; for 24h; |
| Conditions | Yield |
|---|---|
| With hemicucurbituril supported [Bmim]Cl In toluene for 9h; Reflux; | 75% |
| Conditions | Yield |
|---|---|
| With hemicucurbituril supported [Bmim]Cl In toluene for 10h; Reflux; | 75% |
- 75-00-3
chloroethane
- 111-96-6
diethylene glycol dimethyl ether
- 123-30-8
4-amino-phenol
- 90-04-0
2-methoxy-phenylamine
- 156-43-4
4-Ethoxyaniline
| Conditions | Yield |
|---|---|
| With sodium methylate In methanol | 72.1% |
- 136353-33-8
3-Benzyl-2-[(Z)-4-ethoxy-phenylimino]-6-methyl-2,3-dihydro-6H-thiazolo[4,5-d]pyridazin-7-one
A
- 72666-76-3
2-Oxothiazolo<4,5-d>pyridazin-7(6H)-one
B
- 156-43-4
4-Ethoxyaniline
| Conditions | Yield |
|---|---|
| With hydrogenchloride In ethanol for 48h; Heating; | A 62% B n/a |
Phenetidine Chemical Properties
The molecular structure of Phenetidine (CAS NO.156-43-4):
IUPAC Name: 4-Ethoxyaniline
Molecular Weight: 137.17904 g/mol
Molecular Formula: C8H11NO
Density: 1.037 g/cm3
Melting Point: 2-5 °C(lit.)
Boiling Point: 254 °C at 760 mmHg
Flash Point: 110.3 °C
Index of Refraction: 1.544
Molar Refractivity: 41.8 cm3
Molar Volume: 132.2 cm3
Surface Tension: 38.5 dyne/cm
Enthalpy of Vaporization: 49.14 kJ/mol
Vapour Pressure: 0.0177 mmHg at 25 °C
Water Solubility: practically insoluble
Sensitive: air sensitive
XLogP3: 1.2
H-Bond Donor: 1
H-Bond Acceptor: 2
Rotatable Bond Count: 2
Exact Mass: 137.084064
MonoIsotopic Mass: 137.084064
Topological Polar Surface Area: 35.2
Heavy Atom Count: 10
Canonical SMILES: CCOC1=CC=C(C=C1)N
InChI: InChI=1S/C8H11NO/c1-2-10-8-5-3-7(9)4-6-8/h3-6H,2,9H2,1H3
InChIKey: IMPPGHMHELILKG-UHFFFAOYSA-N
EINECS: 205-855-5
Product Categories: INORGANIC & ORGANIC CHEMICALS; Phenetole; Anilines (Building Blocks for Liquid Crystals); Building Blocks for Liquid Crystals; Functional Materials
Phenetidine Uses
Phenetidine (CAS NO.156-43-4) is used as intermediates of medicine, dyes, food preservatives, feed additives and rubber antioxidant.
Phenetidine Toxicity Data With Reference
| 1. | skn-rbt 500 mg MLD | FCTOD7 Food and Chemical Toxicology. 20 (1982),563. | ||
| 2. | eye-rbt 100 mg MOD | FCTOD7 Food and Chemical Toxicology. 20 (1982),563. | ||
| 3. | eye-rbt 100 mg/45 rns MLD | FCTOD7 Food and Chemical Toxicology. 20 (1982),563. | ||
| 4. | mma-sat 1 µmol/plate | CPBTAL Chemical and Pharmaceutical Bulletin. 33 (1985),2877. | ||
| 5. | dni-ham:lng 160 µmol/L | MUTAEX Mutagenesis. 3 (1988),51. | ||
| 6. | orl-rat LD50:580 mg/kg | GISAAA Gigiena i Sanitariya. 35 (8)(1970),28. | ||
| 7. | ihl-rat LCLo:250 mg/m3 | GISAAA Gigiena i Sanitariya. 35 (8)(1970),28. | ||
| 8. | orl-mus LD50:530 mg/kg | GTPZAB Gigiena Truda i Professionalnye Zabolevaniia. Labor Hygiene and Occupational Diseases. 25 (8)(1981),50. | ||
| 9. | ipr-mus LD50:692 mg/kg | JMCMAR Journal of Medicinal Chemistry. 17 (1974),900. |
Phenetidine Consensus Reports
Reported in EPA TSCA Inventory.
Phenetidine Safety Profile
Hazard Codes: 
T, 
Xi, 
Xn
Risk Statements: 23/24/25-33-68-43-36-20/21/22
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed.
R33:Danger of cumulative effects.
R68:Possible risk of irreversible effects.
R43:May cause sensitization by skin contact.
R36:Irritating to eyes.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 28-36/37-45-46
S28:After contact with skin, wash immediately with plenty of soap-suds.
S36/37:Wear suitable protective clothing and gloves.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S46:If swallowed, seek medical advice immediately and show this container or label.
RIDADR: UN 2311 6.1/PG 3
WGK Germany: 1
RTECS: SI6465500
F: 8-10
Hazard Note: Irritant
HazardClass: 6.1
PackingGroup: III
HS Code: 29222200
Poison by inhalation. Moderately toxic by ingestion and intraperitoneal routes. Caution: It can be absorbed through the skin. A skin and eye irritant. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
Phenetidine Specification
Phenetidine (CAS NO.156-43-4) is also named as 1-Amino-4-ethoxybenzene ; 4-13-00-01017 (Beilstein Handbook Reference) ; 4-Aminoethoxybenzene ; 4-Aminophenetole ; 4-Ethoxyaniline ; 4-Ethoxybenzenamine ; AI3-09042 ; Aniline, p-ethoxy- ; BRN 0606666 ; CCRIS 2878 ; CP 5685 ; NSC 3116 ; p-Aminofenetol ; p-Aminofenetol [Czech] ; p-Aminophenetole ; p-Ethoxyaniline ; p-Fenetidin ; p-Fenetidin [Czech] ; p-Phenetidin ; p-Phenetidine . Phenetidine (CAS NO.156-43-4) is colourless liquid. It is slightly soluble in water. It is very sensitive to exposure to air and light. It can turn red to brown on exposure to light and air. Phenetidine reacts vigorously with powerful oxidizers. It is combustible.
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