CAS No.156-43-4,Phenetidine Suppliers

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Basic Information

Molecular Structure:
CAS No.:	156-43-4
Name:	Phenetidine
Article Data:	148

Formula:	C₈H₁₁NO
Molecular Weight:	137.181
Synonyms:	p-Phenetidine(8CI);1-Amino-4-ethoxybenzene;4-Aminophenetole;4-Ethoxyaniline;4-Ethoxybenzenamine;4-Ethoxyphenylamine;4-Phenetidine;NSC 3116;p-Aminophenetole;p-Ethoxyaniline;p-Ethoxyphenylamine;p-Phenetidin;
EINECS:	205-855-5
Density:	1.037 g/cm³
Melting Point:	2-5 °C(lit.)
Boiling Point:	254 °C at 760 mmHg
Flash Point:	110.3 °C
Solubility:	practically insoluble in water
Appearance:	colourless liquid
Hazard Symbols:	T,Xi,Xn
Risk Codes:	23/24/25-33-68-43-36-20/21/22
Safety:	28-36/37-45-46
Transport Information:	UN 2311
PSA:	35.25000
LogP:	2.24870

Synthetic route

: 100-29-8
1-ethoxy-4-nitrobenzene

: 156-43-4
4-Ethoxyaniline

Conditions

Conditions	Yield
With hydrogen In 2-methyltetrahydrofuran; water at 40℃; under 15001.5 Torr; for 24h; chemoselective reaction;	99%
With sodium sulfide; tetrabutylammomium bromide In water; toluene at 80℃; for 0.75h; Zinin reduction;	98.4%
With hydrogen; triethylamine In ethanol; water at 110℃; under 30003 Torr; for 24h; Autoclave;	96%

: 4792-83-0, 51437-64-0
4,4'-diethoxyazoxybenzene

: 156-43-4
4-Ethoxyaniline

Conditions

Conditions	Yield
With N-doped TiO2 In methanol at 20℃; for 3h; UV-irradiation; Inert atmosphere;	99%

: 75-00-3
chloroethane

: 123-30-8
4-amino-phenol

: 156-43-4
4-Ethoxyaniline

Conditions

Conditions	Yield
With sodium hydroxide; dimethyl sulfoxide	90.1%

: 103861-73-0
N-allyl-p-phenetidine

: 156-43-4
4-Ethoxyaniline

Conditions

Conditions	Yield
With polymethylhydrosiloxane; zinc(II) chloride; tetrakis(triphenylphosphine) palladium(0) In tetrahydrofuran at 20℃;	88%

: 141-52-6
sodium ethanolate

: 540-37-4
p-aminoiodobenzene

: 156-43-4
4-Ethoxyaniline

Conditions

Conditions	Yield
With hemicucurbituril supported [Bmim]Cl In toluene for 10h; Reflux;	80%

: 74-96-4
ethyl bromide

: 123-30-8
4-amino-phenol

: 156-43-4
4-Ethoxyaniline

Conditions

Conditions	Yield
With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 24h;	78%
With sodium hydride In acetonitrile at 20℃; for 24h;

: 141-52-6
sodium ethanolate

: 106-47-8
4-chloro-aniline

: 156-43-4
4-Ethoxyaniline

Conditions

Conditions	Yield
With hemicucurbituril supported [Bmim]Cl In toluene for 9h; Reflux;	75%

: 141-52-6
sodium ethanolate

: 106-40-1
4-bromo-aniline

: 156-43-4
4-Ethoxyaniline

Conditions

Conditions	Yield
With hemicucurbituril supported [Bmim]Cl In toluene for 10h; Reflux;	75%

: 75-00-3
chloroethane

: 111-96-6
diethylene glycol dimethyl ether

: 123-30-8
4-amino-phenol

: 90-04-0
2-methoxy-phenylamine

: 156-43-4
4-Ethoxyaniline

Conditions

Conditions	Yield
With sodium methylate In methanol	72.1%

...Expand

: 136353-33-8
3-Benzyl-2-[(Z)-4-ethoxy-phenylimino]-6-methyl-2,3-dihydro-6H-thiazolo[4,5-d]pyridazin-7-one

A: 72666-76-3
2-Oxothiazolo<4,5-d>pyridazin-7(6H)-one

B: 156-43-4
4-Ethoxyaniline

Conditions

Conditions	Yield
With hydrogenchloride In ethanol for 48h; Heating;	A 62% B n/a

Raw Materials

100-65-2

100-02-7

74-96-4

60-29-7

Downstream Products

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Chemistry

The molecular structure of Phenetidine (CAS NO.156-43-4):

IUPAC Name: 4-Ethoxyaniline
Molecular Weight: 137.17904 g/mol
Molecular Formula: C₈H₁₁NO
Density: 1.037 g/cm³
Melting Point: 2-5 °C(lit.)
Boiling Point: 254 °C at 760 mmHg
Flash Point: 110.3 °C
Index of Refraction: 1.544
Molar Refractivity: 41.8 cm³
Molar Volume: 132.2 cm³
Surface Tension: 38.5 dyne/cm
Enthalpy of Vaporization: 49.14 kJ/mol
Vapour Pressure: 0.0177 mmHg at 25 °C
Water Solubility: practically insoluble
Sensitive: air sensitive
XLogP3: 1.2
H-Bond Donor: 1
H-Bond Acceptor: 2
Rotatable Bond Count: 2
Exact Mass: 137.084064
MonoIsotopic Mass: 137.084064
Topological Polar Surface Area: 35.2
Heavy Atom Count: 10
Canonical SMILES: CCOC1=CC=C(C=C1)N
InChI: InChI=1S/C8H11NO/c1-2-10-8-5-3-7(9)4-6-8/h3-6H,2,9H2,1H3
InChIKey: IMPPGHMHELILKG-UHFFFAOYSA-N
EINECS: 205-855-5
Product Categories: INORGANIC & ORGANIC CHEMICALS; Phenetole; Anilines (Building Blocks for Liquid Crystals); Building Blocks for Liquid Crystals; Functional Materials

Uses

Phenetidine (CAS NO.156-43-4) is used as intermediates of medicine, dyes, food preservatives, feed additives and rubber antioxidant.

Toxicity Data With Reference

1.	skn-rbt 500 mg MLD	FCTOD7 Food and Chemical Toxicology. 20 (1982),563.
2.	eye-rbt 100 mg MOD	FCTOD7 Food and Chemical Toxicology. 20 (1982),563.
3.	eye-rbt 100 mg/45 rns MLD	FCTOD7 Food and Chemical Toxicology. 20 (1982),563.
4.	mma-sat 1 µmol/plate	CPBTAL Chemical and Pharmaceutical Bulletin. 33 (1985),2877.
5.	dni-ham:lng 160 µmol/L	MUTAEX Mutagenesis. 3 (1988),51.
6.	orl-rat LD50:580 mg/kg	GISAAA Gigiena i Sanitariya. 35 (8)(1970),28.
7.	ihl-rat LCLo:250 mg/m³	GISAAA Gigiena i Sanitariya. 35 (8)(1970),28.
8.	orl-mus LD50:530 mg/kg	GTPZAB Gigiena Truda i Professionalnye Zabolevaniia. Labor Hygiene and Occupational Diseases. 25 (8)(1981),50.
9.	ipr-mus LD50:692 mg/kg	JMCMAR Journal of Medicinal Chemistry. 17 (1974),900.

Consensus Reports

Reported in EPA TSCA Inventory.

Safety Profile

Hazard Codes: Toxic T, Irritant Xi, Harmful Xn
Risk Statements: 23/24/25-33-68-43-36-20/21/22
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed.
R33:Danger of cumulative effects.
R68:Possible risk of irreversible effects.
R43:May cause sensitization by skin contact.
R36:Irritating to eyes.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 28-36/37-45-46
S28:After contact with skin, wash immediately with plenty of soap-suds.
S36/37:Wear suitable protective clothing and gloves.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S46:If swallowed, seek medical advice immediately and show this container or label.
RIDADR: UN 2311 6.1/PG 3
WGK Germany: 1
RTECS: SI6465500
F: 8-10
Hazard Note: Irritant
HazardClass: 6.1
PackingGroup: III
HS Code: 29222200
Poison by inhalation. Moderately toxic by ingestion and intraperitoneal routes. Caution: It can be absorbed through the skin. A skin and eye irritant. Mutation data reported. When heated to decomposition it emits toxic fumes of NO_x.

Specification

Phenetidine (CAS NO.156-43-4) is also named as 1-Amino-4-ethoxybenzene ; 4-13-00-01017 (Beilstein Handbook Reference) ; 4-Aminoethoxybenzene ; 4-Aminophenetole ; 4-Ethoxyaniline ; 4-Ethoxybenzenamine ; AI3-09042 ; Aniline, p-ethoxy- ; BRN 0606666 ; CCRIS 2878 ; CP 5685 ; NSC 3116 ; p-Aminofenetol ; p-Aminofenetol [Czech] ; p-Aminophenetole ; p-Ethoxyaniline ; p-Fenetidin ; p-Fenetidin [Czech] ; p-Phenetidin ; p-Phenetidine . Phenetidine (CAS NO.156-43-4) is colourless liquid. It is slightly soluble in water. It is very sensitive to exposure to air and light. It can turn red to brown on exposure to light and air. Phenetidine reacts vigorously with powerful oxidizers. It is combustible.