3-Methoxyphenyloxytrimethylsilane

Base Information

• Chemical Name: 3-Methoxyphenyloxytrimethylsilane
• CAS No.: 33285-71-1
• Molecular Formula: C10H16O2Si
• Molecular Weight: 196.321
• Hs Code.: 2931900090
• Mol file: 33285-71-1.mol

Synonyms:m-Anisyl-trimethylsilyloxid;m-Methoxyphenoxytrimethylsilan;m-Methoxyphenol-trimethylsilylether;Trimethyl-(m-methoxyphenoxy)-silan;m-Methoxyphenyltrimethylsilylaether;1-methoxy-3-trimethylsilyloxybenzene;

Chemical Property of 3-Methoxyphenyloxytrimethylsilane

Chemical Property:

• PSA: 18.46000
• LogP: 2.90890

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Methoxyphenyloxytrimethylsilane

There total 6 articles about 3-Methoxyphenyloxytrimethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

O-methylresorcine (150-19-6) + 1,1,1,3,3,3-hexamethyl-disilazane (999-97-3) → 1-methoxy-3-trimethylsilyloxybenzene (33285-71-1)

Guidance literature:

at 80 ℃; for 3h; Inert atmosphere;

DOI:10.1021/acs.joc.5b01634

Reference yield:

chloro-trimethyl-silane (75-77-4) + O-methylresorcine (150-19-6) → 1-methoxy-3-trimethylsilyloxybenzene (33285-71-1)

Guidance literature:

O-methylresorcine; With triethylamine; In dichloromethane; for 0.166667h; Inert atmosphere;

chloro-trimethyl-silane; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1021/acs.joc.8b03188

Reference yield:

methoxybenzene (100-66-3) → 1-methoxy-3-trimethylsilyloxybenzene (33285-71-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 2-(t-butylazo)prop-2-yl hydroperoxide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / benzene / 44.84 °C

1.2: 2 h / 75 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 0.17 h / Inert atmosphere

2.2: 20 °C / Inert atmosphere

With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; 2-(t-butylazo)prop-2-yl hydroperoxide; triethylamine; In dichloromethane; benzene;

DOI:10.1021/acs.joc.8b03188

upstream raw materials:

O-methylresorcine

N,O-bis-(trimethylsilyl)-acetamide

3-methoxyphenyl bromide

bis-trimethylsilanyl peroxide

Downstream raw materials:

3-methoxyphenyl 2,2-dimethylpropionate

3-methoxyphenyl 3-phenylpropionate

(2R,3R,4S,5R,6S)-3,4,5-tris(benzyloxy)-2-((benzyloxy)methyl)-6-(3-methoxyphenoxy)tetrahydro-2H-pyran

(2R,3R,4S,5R,6R)-3,4,5-tris(benzyloxy)-2-((benzyloxy)methyl)-6-(3-methoxyphenoxy)tetrahydro-2H-pyran