2,5-Diethoxybenzaldehyde

Base Information

• Chemical Name: 2,5-Diethoxybenzaldehyde
• CAS No.: 4686-98-0
• Molecular Formula: C11H14O3
• Molecular Weight: 194.23
• Hs Code.: 2912499000
• DSSTox Substance ID: DTXSID30392445
• Nikkaji Number: J185.775D
• Wikidata: Q82190686
• Mol file: 4686-98-0.mol

Synonyms:2,5-Diethoxybenzaldehyde;4686-98-0;SCHEMBL271557;2,5-Diethoxybenzaldehyde, 97%;DTXSID30392445;UGNJILDLOHTRMK-UHFFFAOYSA-N;MFCD02093696;AKOS003809429;CS-0364980

Chemical Property of 2,5-Diethoxybenzaldehyde

Chemical Property:

• Vapor Pressure: 0.00035mmHg at 25°C
• Melting Point: 59-63oC(lit.)
• Boiling Point: 318.9oC at 760 mmHg
• Flash Point: 137.7oC
• PSA: 35.53000
• Density: 1.066g/cm3
• LogP: 2.29650
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 194.094294304
• Heavy Atom Count: 14
• Complexity: 170

Purity/Quality:

98%min ^*data from raw suppliers

2,5-Diethoxybenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CCOC1=CC(=C(C=C1)OCC)C=O

Technology Process of 2,5-Diethoxybenzaldehyde

There total 7 articles about 2,5-Diethoxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Dichloromethyl methyl ether (4885-02-3) + 1,4-diethoxybenzene (122-95-2) → 2,5-diethoxybenzaldehyde (4686-98-0)

Guidance literature:

With hydrogenchloride; tin(IV) chloride; In dichloromethane;

Reference yield:

ethyl bromide (74-96-4) + 2,5-Dihydroxybenzaldehyde (1194-98-5) → 2,5-diethoxybenzaldehyde (4686-98-0)

Guidance literature:

2,5-Dihydroxybenzaldehyde; With potassium carbonate; potassium iodide; In acetone; at 50 ℃; for 0.5h;

ethyl bromide; In acetone; at 80 - 85 ℃; for 12h;

DOI:10.1016/j.bioorg.2020.104239

Reference yield:

2,5-Dihydroxybenzaldehyde (1194-98-5) + ethyl iodide (75-03-6) → 2,5-diethoxybenzaldehyde (4686-98-0)

Guidance literature:

With potassium carbonate; In acetone; at 50 - 60 ℃;

DOI:10.1021/jm950639r

upstream raw materials:

hydrogen cyanide

1,4-diethoxybenzene

2,5-Dihydroxybenzaldehyde

ethyl iodide

Downstream raw materials:

2,5-diethoxybenzyl alcohol

2-Benzylamino-5,8-diethoxy-1,2,3,4-tetrahydro-naphthalene-2-carbonitrile

(2-Aminomethyl-5,8-diethoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-benzyl-amine

Benzyl-(5,8-diethoxy-3,4-dihydro-naphthalen-2-yl)-amine

Refernces

• 1、 Santra,Kovalev,Kopchuk,Zyryanov,Majee,Charushin,Chupakhin. "Role of polar solvents for the synthesis of pillar[6]arenes". . p. 104284 - 104288. Retrieved 2015/12/30.
• 2、 -. "Anthracyclines". . . Retrieved 2008/06/13.