N-methyl-2-naphthalen-1-yloxyethanamine

Base Information

• Chemical Name: N-methyl-2-naphthalen-1-yloxyethanamine
• CAS No.: 50882-69-4
• Molecular Formula: C13H15NO
• Molecular Weight: 201.26400
• Hs Code.: 2922299090
• DSSTox Substance ID: DTXSID40366950
• Nikkaji Number: J925.626A
• Wikidata: Q82152461
• Pharos Ligand ID: 6R6WWMM38FJK
• ChEMBL ID: CHEMBL138958
• Mol file: 50882-69-4.mol

Synonyms:N-methyl-2-naphthalen-1-yloxyethanamine;50882-69-4;N-methyl-2-(naphthalen-1-yloxy)ethanamine;N-methyl-N-[2-(1-naphthyloxy)ethyl]amine;CHEMBL138958;Ethanamine, N-methyl-2-(1-naphthalenyloxy)-;Methyl-[2-(naphthalen-1-yloxy)-ethyl]-amine;SCHEMBL6846952;DTXSID40366950;GYIQQYDOLSGVHC-UHFFFAOYSA-N;BDBM50061971;STL068222;AKOS005261358;N-Methyl-2-(1-naphthyloxy)ethanamine;CCG-357168;ICX5600023;N-methyl-2-(naphthyl-1-oxy)ethanamine;AN-329/43450080;METHYL[2-(NAPHTHALEN-1-YLOXY)ETHYL]AMINE;A1-05619

Chemical Property of N-methyl-2-naphthalen-1-yloxyethanamine

Chemical Property:

• PSA: 21.26000
• LogP: 2.82890
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 201.115364102
• Heavy Atom Count: 15
• Complexity: 183

Purity/Quality:

N-Methyl-2-naphthalen-1-yloxyethanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CNCCOC1=CC=CC2=CC=CC=C21

Technology Process of N-methyl-2-naphthalen-1-yloxyethanamine

There total 7 articles about N-methyl-2-naphthalen-1-yloxyethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

2-(naphthalen-1-yloxy)ethyl 4-toluenesulfonate (60225-63-0) + methylamine (74-89-5) → N-methyl-N-[2-(1-naphthyloxy)ethyl]amine (50882-69-4)

Guidance literature:

With potassium carbonate; In 1,4-dioxane; ethanol; for 3h; Heating;

DOI:10.1021/jm970507t

Reference yield:

α-naphthol (90-15-3) → N-methyl-N-[2-(1-naphthyloxy)ethyl]amine (50882-69-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 2 N aq. NaOH / 2 h / Heating

2: pyridine / 48 h / 0 - 10 °C

3: 50 percent / K₂CO₃ / ethanol; dioxane / 3 h / Heating

With pyridine; sodium hydroxide; potassium carbonate; In 1,4-dioxane; ethanol;

DOI:10.1021/jm970507t

Reference yield:

2-(1-naphthyloxy)-1-ethanol (711-82-0) → N-methyl-N-[2-(1-naphthyloxy)ethyl]amine (50882-69-4)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 48 h / 0 - 10 °C

2: 50 percent / K₂CO₃ / ethanol; dioxane / 3 h / Heating

With pyridine; potassium carbonate; In 1,4-dioxane; ethanol;

DOI:10.1021/jm970507t

upstream raw materials:

2-(naphthalen-1-yloxy)ethyl 4-toluenesulfonate

methylamine

1-(2-bromoethoxy)naphthalene

α-naphthol