Tyrosine, O-methyl-, methyl ester

Base Information

• Chemical Name: Tyrosine, O-methyl-, methyl ester
• CAS No.: 61780-18-5
• Molecular Formula: C11H15NO3
• Molecular Weight: 209.245
• Mol file: 61780-18-5.mol

Synonyms:O-Methyl-tyrosin-methylester;O-Methyl-dl-tyrosin-methylester;2-Amino-3-(4-methoxy-phenyl)-propionic acid methyl ester;O-methyl-tyrosine methyl ester;

Chemical Property of Tyrosine, O-methyl-, methyl ester

Chemical Property:

• Boiling Point: 158 °C (12 mmHg)
• PSA: 61.55000
• LogP: 1.43830

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Tyrosine, O-methyl-, methyl ester

There total 20 articles about Tyrosine, O-methyl-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(2R)-tert-butoxycarbonylamino-3-(4-methoxyphenyl)propionic acid methyl ester (94790-24-6) → methyl (R)-2-amino-3-(4-methoxyphenyl)propanoate (17355-19-0,61780-18-5,120349-74-8)

Guidance literature:

With trifluoroacetic acid; In dichloromethane;

DOI:10.1021/ol017016u

Reference yield: 99.0%

methyl-α-azido-β-(4-methoxyphenyl)propionate → methyl 2-amino-3-(4-methoxyphenyl) propanoate (61780-18-5)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; for 5h; under 1810.02 Torr;

DOI:10.1080/00397919508011832

Reference yield: 92.0%

methanol (67-56-1) + (R)-β-(4-methoxyphenyl)alanine (39878-65-4) → methyl (R)-2-amino-3-(4-methoxyphenyl)propanoate (17355-19-0,61780-18-5,120349-74-8)

Guidance literature:

methanol; (R)-β-(4-methoxyphenyl)alanine; With sulfuric acid; In water; at 20 ℃;

With sodium hydrogencarbonate; sodium hydroxide; In water; pH=8 - 9;

upstream raw materials:

diazomethane

?Tyr

diethyl ether

ethanol

Downstream raw materials:

methyl α-(4-methoxybenzyl)diazoacetate

3,4-bis(4-methoxyphenyl)-1H-pyrrole-2,5-dicarboxylic acid

3,4-bis(4-methoxyphenyl)-1H-pyrrole-2,5-dicarboxylic acid dimethyl ester

trimethyl (2R,3S,4R,5S)-2-(4-methoxybenzyl)-5-(4-nitrophenyl)pyrrolidine-2,3,4-tricarboxylate