3-(N,N-dimethylaminomethyl)-1-methylindole

Base Information

• Chemical Name: 3-(N,N-dimethylaminomethyl)-1-methylindole
• CAS No.: 52972-61-9
• Molecular Formula: C12H16 N2
• Molecular Weight: 188.272
• Mol file: 52972-61-9.mol

Synonyms:Indole,3-(dimethylaminomethyl)-1-methyl- (6CI);1-Methyl-3-(dimethylaminomethyl)indole; 1-Methylgramine; 3-(Dimethylaminomethyl)-1-methylindole; NSC 360214

Chemical Property of 3-(N,N-dimethylaminomethyl)-1-methylindole

Chemical Property:

• Vapor Pressure: 0.00202mmHg at 25°C
• Boiling Point: 290.9°Cat760mmHg
• Flash Point: 129.7°C
• PSA: 8.17000
• Density: 1g/cm³
• LogP: 2.23990

Purity/Quality:

99% ^*data from raw suppliers

N,N,1-TRIMETHYL-1H-INDOLE-3-METHANAMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(N,N-dimethylaminomethyl)-1-methylindole

There total 6 articles about 3-(N,N-dimethylaminomethyl)-1-methylindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-methylindole (603-76-9) + formaldehyd (50-00-0,30525-89-4,61233-19-0) + dimethyl amine (124-40-3) → 3-(N,N-dimethylaminomethyl)-1-methylindole (52972-61-9)

Guidance literature:

1-methylindole; formaldehyd; dimethyl amine; With acetic acid; In water; at 0 - 50 ℃;

With sodium hydroxide; In water;

DOI:10.1021/om901031m

Reference yield: 81.0%

1-methylindole (603-76-9) + bis-(dimethylamino)methane (51-80-9) → 3-(N,N-dimethylaminomethyl)-1-methylindole (52972-61-9)

Guidance literature:

With sulfur dioxide; In acetonitrile; at 0 - 20 ℃; for 48h;

DOI:10.1016/S0040-4020(97)00848-X

Reference yield: 75.0%

3-(Dimethylaminomethyl)indole (87-52-5) + methyl iodide (74-88-4) → 3-(N,N-dimethylaminomethyl)-1-methylindole (52972-61-9)

Guidance literature:

With sodium hydride; In dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(00)81442-2

upstream raw materials:

1-methylindole

formaldehyd

dimethyl amine

bis-(dimethylamino)methane

Downstream raw materials:

isopropylidene benzyl<(N-methylindol-3-yl)methyl>malonate

2,5,6-tribromo-N-methylgramine

benzyl<(N-methylindol-3-yl)methyl>malonic acid

N-methyl-3-formylindole