1-(TERT-BUTOXYCARBONYL)-3-(DIMETHYLAMINO)AZETIDINE

Base Information

• Chemical Name: 1-(TERT-BUTOXYCARBONYL)-3-(DIMETHYLAMINO)AZETIDINE
• CAS No.: 792970-55-9
• Molecular Formula: C10H20N2O2
• Molecular Weight: 200.28
• Mol file: 792970-55-9.mol

Synonyms:

Chemical Property of 1-(TERT-BUTOXYCARBONYL)-3-(DIMETHYLAMINO)AZETIDINE

Chemical Property:

• Boiling Point: 255.9±33.0 °C(Predicted)
• PKA: 7.78±0.20(Predicted)
• Density: 1.03±0.1 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

Ethyl 8-hydroxy-7-quinolinecarboxylate AldrichCPR ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(TERT-BUTOXYCARBONYL)-3-(DIMETHYLAMINO)AZETIDINE

There total 7 articles about 1-(TERT-BUTOXYCARBONYL)-3-(DIMETHYLAMINO)AZETIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl 3-oxoazetidine-1-carboxylate (398489-26-4) + dimethyl amine (124-40-3) → tert-butyl 3-(dimethylamino)azetidine-1-carboxylate (792970-55-9)

Guidance literature:

tert-butyl 3-oxoazetidine-1-carboxylate; dimethyl amine; With hydrogen; acetic acid; palladium 10% on activated carbon; In tetrahydrofuran; methanol; at 20 ℃; for 14h;

With sodium hydrogencarbonate; In water; ethyl acetate;

Reference yield: 85.0%

tert-butyl 3-oxoazetidine-1-carboxylate (398489-26-4) + N,N-dimethylammonium chloride (506-59-2) → tert-butyl 3-(dimethylamino)azetidine-1-carboxylate (792970-55-9)

Guidance literature:

With palladium on activated charcoal; hydrogen; acetic acid; In methanol; at 20 ℃; for 48h; Inert atmosphere;

Reference yield: 83.0%

3-aminoazetidine-1-carboxylic acid tert-butyl ester (193269-78-2) + formaldehyd (50-00-0,30525-89-4,61233-19-0) → tert-butyl 3-(dimethylamino)azetidine-1-carboxylate (792970-55-9)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; water; at 20 ℃; for 18h; under 775.743 Torr;

upstream raw materials:

tert-butyl 3-oxoazetidine-1-carboxylate

dimethyl amine

tert-butyl-3-iodoazetidine-1-carboxylate

di-tert-butyl dicarbonate

Downstream raw materials:

N,N-dimethylazetidin-3-amine monohydrochloride

3-(dimethylamino)azetidine dihydrochloride