CIS-1,3-CYCLOHEXANEDICARBOXYLIC ANHYDRIDE

Base Information

• Chemical Name: CIS-1,3-CYCLOHEXANEDICARBOXYLIC ANHYDRIDE
• CAS No.: 4355-31-1
• Molecular Formula: C8H10O3
• Molecular Weight: 154.166
• Hs Code.: 2917209090
• Mol file: 4355-31-1.mol

Synonyms:cis-cyclohexane-1,3-dicarboxylic acid-anhydride;cis-Cyclohexan-1,3-dicarbonsaeure-anhydrid;1,3-cyclohexane dicarboxylic acid anhydride;cyclohexane-1,3-dicarboxylic acid anhydride;cis-1,3-Cyclohexanedicarboxylic anhydride;Cyclohexan-1,3-dicarbonsaeure-anhydrid;3-oxabicyclo [3.3.1] nonane-2,4-dione;

Chemical Property of CIS-1,3-CYCLOHEXANEDICARBOXYLIC ANHYDRIDE

Chemical Property:

• Vapor Pressure: 0.00111mmHg at 25°C
• Melting Point: 188-189 °C
• Boiling Point: 300.6°Cat760mmHg
• Flash Point: 143.9°C
• PSA: 43.37000
• Density: 1.235g/cm³
• LogP: 0.87620
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

cis-1,3-Cyclohexanedicarboxylicanhydride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of CIS-1,3-CYCLOHEXANEDICARBOXYLIC ANHYDRIDE

There total 2 articles about CIS-1,3-CYCLOHEXANEDICARBOXYLIC ANHYDRIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

cyclohexane-1,3-dicarboxylic acid (3971-31-1) + dicyclohexyl-carbodiimide (538-75-0) → 1,3-Dicyclohexylurea (2387-23-7) + 3-oxabicyclo[3.3.1]nonane-2,4-dione (4355-31-1)

Guidance literature:

In dichloromethane; at 20 ℃; for 4h;

Reference yield: 87.7%

orthoformic acid triethyl ester (122-51-0) → cis-1,3-Cyclohexanedicarboxylic acid diethyl ester (62059-56-7) + 3-oxabicyclo[3.3.1]nonane-2,4-dione (4355-31-1)

Guidance literature:

With p-toluenesulfonic acid monohydrate; In ethanol; hexane; ethyl acetate;

Reference yield: 97.0%

methanol (67-56-1) + 3-oxabicyclo<3.3.1>nonane-2,4-dione (4355-31-1) → (1R,3S)-3-(methoxycarbonyl)cyclohexanecarboxylic acid (227783-07-5)

Guidance literature:

With 1-((1R,2R)-2-(dimethylamino)cyclohexyl)-3-phenylthiourea; In diethyl ether; at 20 ℃; for 24h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1016/j.tet.2010.04.121

upstream raw materials:

cyclohexane-1,3-dicarboxylic acid

dicyclohexyl-carbodiimide

orthoformic acid triethyl ester

Downstream raw materials:

cis-3-(methoxycarbonyl)cyclohexanecarboxylic acid

3-phenyl-3-aza-bicyclo[3.3.1]nonane-2,4-dione

3-Methyl-3-aza-bicyclo<3.3.1>nonan-methoiodid

[2-(3-aza-bicyclo[3.3.1]non-3-yl)-ethyl]-trimethyl-ammonium; iodide