ETHYL METHYLPHOSPHONIC ACID

Base Information

• Chemical Name: ETHYL METHYLPHOSPHONIC ACID
• CAS No.: 1832-53-7
• Molecular Formula: C3H9 O3 P
• Molecular Weight: 124.076
• Hs Code.: 2931900090
• Mol file: 1832-53-7.mol

Synonyms:Phosphonicacid, methyl-, ethyl ester (6CI,7CI); Phosphonic acid, methyl-, monoethyl ester(8CI,9CI); EMPA; Ethyl hydrogen methylphosphonate; Ethyl methylphosphonate;Monoethyl methylphosphonate

Chemical Property of ETHYL METHYLPHOSPHONIC ACID

Chemical Property:

• Refractive Index: n20/D 1.426(lit.)
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 56.34000
• Density: g/cm³
• LogP: 0.83810
• Storage Temp.: ?20°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

EMPA ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T,F
• Statements: 25-36/37/38-39/23/24/25-23/24/25-11
• Safety Statements: 26-36-45-36/37-16

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: EMPA is a novel high-affinity, selective antagonist for the OX2 receptor.

Technology Process of ETHYL METHYLPHOSPHONIC ACID

There total 34 articles about ETHYL METHYLPHOSPHONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

O-ethyl S-(2-diisopropylaminoethyl) methylphosphonothiolate (65143-05-7,65167-63-7,65167-64-8,50782-69-9,51848-47-6,53800-40-1,70938-84-0) → ethyl methylphosphonic acid (1832-53-7) + S-<2-(diisopropylamino)ethyl> methylphosphonothioic acid (73207-98-4)

Guidance literature:

With sodium hydroxide; In water; at 22 ℃;

DOI:10.1021/ic200007v

Reference yield: 80.0%

ethanol (64-17-5) + methylphosphonic acid (993-13-5) → ethyl methylphosphonic acid (1832-53-7)

Guidance literature:

With Celite; dicyclohexyl-carbodiimide; at 20 ℃; for 0.5h;

DOI:10.1016/j.tetlet.2008.01.016

Reference yield: 79.0%

1,1,2,2-tetrabromoethane (79-27-6) + Diethyl methylphosphonate (683-08-9) → ethyl bromide (74-96-4) + 1,1,2-tribromoethylene (598-16-3) + ethyl methylphosphonic acid (1832-53-7)

Guidance literature:

at 180 ℃; for 10h;

DOI:10.1134/S1070363206070293

upstream raw materials:

sodium diethyl phosphite

methyl iodide

ethanol

methylphosphonothioic acid

Downstream raw materials:

Diethyl methylphosphonate

Refernces

• 1、 Aschmann, Sara M.,Tuazon, Ernesto C.,Atkinson, Roger. "Atmospheric chemistry of diethyl methylphosphonate, diethyl ethylphosphonate, and triethyl phosphate". . p. 2282 - 2291. Retrieved 2005.
• 2、 Dong, Jing,Lv, Hongjin,Sun, Xiangrong,Wang, Yin,Ni, Yuanman,Zou, Bo,Zhang, Nan,Yin, Anxiang,Chi, Yingnan,Hu, Changwen. "A Versatile Self-Detoxifying Material Based on Immobilized Polyoxoniobate for Decontamination of Chemical Warfare Agent Simulants". . p. 19208 - 19215. Retrieved 2018.
• 3、 Bigley, Andrew N.,Xu, Chengfu,Henderson, Terry J.,Harvey, Steven P.,Raushel, Frank M.. "Enzymatic neutralization of the chemical warfare agent VX: Evolution of phosphotriesterase for phosphorothiolate hydrolysis". . p. 10426 - 10432. Retrieved 2013.
• 4、 Polec, Iwona,Kielczewska, Anna,Konopski, Leszek,Oleksa, Grazyna,Krukowska, Hanna Nowacka,Legocki, Jan. "Alkyl methylphosphonic acids, the degradation products of organophosphorous CWA - preparation and direct quantitative GC-FID analysis". . p. 1251 - 1265. Retrieved 2010.
• 5、 Gupta,Palit,Dubey,Raza. "Analysis of chemical neutralization products of phosphonothiolates by gas chromatography mass spectrometry". . p. 1631 - 1637. Retrieved 2003.
• 6、 Li, Heguo,Pan, Hongjie,Tao, Cheng-An,Wang, Lingyun,Yang, Guang,Zhang, Shouxin,Zhou, Chuan. "Synthesis of macroscopic monolithic metal-organic gels for ultra-fast destruction of chemical warfare agents". . p. 22125 - 22130. Retrieved 2021/07/02.
• 7、 Andrae, Beatrice,Bauer, Daniel,Ga?, Patrick,Koller, Marianne,Kubik, Stefan,Worek, Franz. "Influence of cyclic and acyclic cucurbiturils on the degradation pathways of the chemical warfare agent VX". supporting information. p. 5218 - 5227. Retrieved 2020/07/23.