4-methylisoindole-1,3-dione

Base Information

• Chemical Name: 4-methylisoindole-1,3-dione
• CAS No.: 7251-82-3
• Molecular Formula: C9H7NO2
• Molecular Weight: 161.1574
• Mol file: 7251-82-3.mol

Synonyms:1H-2-Benzopyran-1-one,4-methyl;3-Methylphthalimide;4-methyl-isochromen-1-one;4-methyl-1H-isochromen-1-one;4-methyl-isoindole-1,3-dione;4-Methylisocumarin;4-methylisocoumarin;3-Methylphthalimid;4-methyl-isoindoline-1,3-dione;

Chemical Property of 4-methylisoindole-1,3-dione

Chemical Property:

• Melting Point: 183-189oC
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 46.17000
• Density: 1.301g/cm³
• LogP: 1.20740

Purity/Quality:

95% ^*data from raw suppliers

4-methylisoindoline-1,3-dione ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-methylisoindole-1,3-dione

There total 18 articles about 4-methylisoindole-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

7-methyl-1-indanone (39627-61-7) → 3-Methylphthalimide (7251-82-3)

Guidance literature:

With manganese(IV) oxide; ammonium hydroxide; oxygen; chlorobenzene; In N,N-dimethyl-formamide; at 100 ℃; for 24h; under 15001.5 Torr; Autoclave; Green chemistry;

Reference yield: 70.0%

3-methylphthalic acid anhydride (4792-30-7) → 3-Methylphthalimide (7251-82-3)

Guidance literature:

With urea; for 0.666667h; Heating;

Reference yield: 36.0%

2,6-dimethylbenzamide (55321-98-7) → 3-Methylphthalimide (7251-82-3)

Guidance literature:

With chromium(VI) oxide; acetic acid; at 20 ℃; for 2h;

DOI:10.1016/S0014-827X(98)00057-3

upstream raw materials:

phthalimide

formaldehyd

3-methylphthalonitrile

3-methylphthalic acid

Downstream raw materials:

3-methylphthalamide

4-methyl-2,3-dihydro-1H-isoindole

2,3-Dihydro-2,4-dimethyl-1H-isoindole-1,3-dione

Refernces

Structural elucidation of an oxidation product of sedimentary porphyrins by one-pot synthesis of 3-methylphthalimide

10.1246/bcsj.74.1975

Shinya Nomoto et al. report the development of a one-pot synthesis method for 3-methylphthalimide starting from 1,2,3-trimethylbenzene. The process involves multiple steps, including bromination, nitric acid oxidation, conversion to an anhydride, and a thermal reaction with urea. The synthesized 3-methylphthalimide was confirmed to be identical to an oxidation product of sedimentary porphyrins previously identified by Barwise and Whitehead. Sedimentary porphyrins, which are complex mixtures resulting from the diagenetic modification of chlorophylls, have substitution patterns that can be determined after decomposition to maleimides. The study's findings provide a practical method for synthesizing 3-methylphthalimide, which is not commercially available, and offer insights into the precursors of benzoporphyrins in geological samples.

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