3-Methoxypyridine

Base Information

• Chemical Name: 3-Methoxypyridine
• CAS No.: 7295-76-3
• Molecular Formula: C6H7NO
• Molecular Weight: 109.128
• Hs Code.: 29333999
• European Community (EC) Number: 230-730-7
• UNII: XV2A2D8595
• DSSTox Substance ID: DTXSID60223238
• Nikkaji Number: J110.373C
• Wikidata: Q27294012
• Mol file: 7295-76-3.mol

Synonyms:3-METHOXYPYRIDINE;7295-76-3;Pyridine, 3-methoxy-;3-methoxy-pyridine;beta-Methoxypyridine;.beta.-Methoxypyridine;MFCD00673022;UNII-XV2A2D8595;XV2A2D8595;EINECS 230-730-7;3-methoxypiridine;ss--Methoxypyridine;3-Methoxypyridine, 97%;SCHEMBL162478;SCHEMBL12015258;DTXSID60223238;BCP32229;BBL103282;STL557092;AKOS015851686;AB06864;CS-W008119;PS-9281;AC-33353;BP-12699;SY024150;AM20061683;FT-0616019;M2304;EN300-67373;A837685;W-104472;Q27294012

Chemical Property of 3-Methoxypyridine

Chemical Property:

• Appearance/Colour: Clear colorless to slightl yellow liquid
• Melting Point: 203 °C
• Refractive Index: n20/D 1.518(lit.)
• Boiling Point: 168.015 °C at 760 mmHg
• PKA: 4.78(at 25℃)
• Flash Point: 58.79 °C
• PSA: 22.12000
• Density: 1.023 g/cm³
• LogP: 1.09020
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 109.052763847
• Heavy Atom Count: 8
• Complexity: 65.5

Purity/Quality:

99% ^*data from raw suppliers

3-Methoxypyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: COC1=CN=CC=C1
• Uses: 3-Methoxypyridine was used in the study of structure-activity relationships of pyridines as Sir2 histone/protein deacetylase inhibitors. 3-Methoxypyridine may be employed as a catalyst for the addition reaction of various 1,2-acyclic diones to activated acetylenic esters.

Technology Process of 3-Methoxypyridine

There total 37 articles about 3-Methoxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.66%

3-methoxypyridine N-oxide (14906-61-7) → 3-methoxypyridine (7295-76-3,1232006-42-6)

Guidance literature:

With iron(III) chloride; pyrographite; hydrazine hydrate; In ethanol; at 70 ℃; for 4h;

Reference yield: 95.0%

3-Chloropyridine (626-60-8) + potassium methanolate (865-33-8) → 3-methoxypyridine (7295-76-3,1232006-42-6)

Guidance literature:

With 18-crown-6 ether; nonane; at 100 ℃; for 0.75h; Further Variations:; Temperatures; Reagents; Product distribution; microwave irradiation;

DOI:10.3987/com-03-9921

Reference yield: 78.0%

3-Bromopyridine (626-55-1,163928-56-1) + methanol (67-56-1) → 3-methoxypyridine (7295-76-3,1232006-42-6)

Guidance literature:

With 5-(di(adamantan-1-yl)phosphino)-1′,3′,5′-triphenyl-1′H-1,4′-bipyrazole; palladium diacetate; caesium carbonate; In toluene; at 80 ℃; for 24h;

DOI:10.1002/chem.201103347

upstream raw materials:

diazomethane

3-HYDROXYPYRIDINE

diethyl ether

methanol

Downstream raw materials:

3-methoxypyridine N-oxide

1-(4-chloro-benzyl)-3-methoxy-pyridinium; chloride

1-(2-chloro-benzyl)-3-methoxy-pyridinium; chloride

1-(2,4-dinitrophenyl)-3-methoxypyridinium chloride