4-(Methoxymethyl)phenol

Base Information

• Chemical Name: 4-(Methoxymethyl)phenol
• CAS No.: 5355-17-9
• Molecular Formula: C8H10O2
• Molecular Weight: 138.166
• Hs Code.: 2909500000
• European Community (EC) Number: 226-334-9
• UNII: 17CJ5983VN
• DSSTox Substance ID: DTXSID2074746
• Nikkaji Number: J217.921K
• Wikidata: Q27251899
• ChEMBL ID: CHEMBL3929528
• Mol file: 5355-17-9.mol

Synonyms:4-(methoxymethyl)phenol

Chemical Property of 4-(Methoxymethyl)phenol

Chemical Property:

• Melting Point: 82.5-83.5 °C
• Boiling Point: 222.8 °C at 760 mmHg
• PKA: 9.84±0.26(Predicted)
• Flash Point: 92.5 °C
• PSA: 29.46000
• Density: 1.087 g/cm³
• LogP: 1.53860
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 138.068079557
• Heavy Atom Count: 10
• Complexity: 85.3

Purity/Quality:

97% ^*data from raw suppliers

4-(Methoxymethyl)phenol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COCC1=CC=C(C=C1)O

Technology Process of 4-(Methoxymethyl)phenol

There total 24 articles about 4-(Methoxymethyl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methanol (67-56-1) + 4-hydroxybenzyl acetate (80767-12-0) → 4-hydroxybenzyl methyl ether (5355-17-9)

Guidance literature:

for 0.5h; Heating;

DOI:10.1016/S0040-4039(00)99619-9

Reference yield: 95.0%

methanol (67-56-1) + (4-hydroxyphenyl)methanol (623-05-2) → 4-hydroxybenzyl methyl ether (5355-17-9) + 1-methoxy-4-(methoxymethyl)benzene (1515-81-7)

Guidance literature:

With sodium hydrogen sulfate; silica gel; In dichloromethane; at 20 ℃; for 1.5h;

DOI:10.1081/SCC-200028584

Reference yield: 92.0%

methanol (67-56-1) + 4-(acetyloxy)benzyl acetate (2937-64-6) → 4-hydroxybenzyl methyl ether (5355-17-9)

Guidance literature:

With sodium acetate; for 3h; Heating;

DOI:10.1021/jo952269k

upstream raw materials:

methanol

(4-hydroxyphenyl)methanol

sodium methylate

8-Ethoxycarbonyloxy-3-(4-ethoxycarbonyloxy-benzyl)-3,6,11-trimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocinium; iodide

Downstream raw materials:

(4-Methoxymethyl-phenoxy)-trimethyl-silane

1-ethoxymethoxy-4-methoxymethylbenzene

4-hydroxy-benzaldehyde

1-ethoxymethoxy-4-methylbenzene