METHANE, BIS-(o-METHOXYPHENYL)-

Base Information

• Chemical Name: METHANE, BIS-(o-METHOXYPHENYL)-
• CAS No.: 5819-93-2
• Molecular Formula: C15H16O2
• Molecular Weight: 228.291
• NSC Number: 78834
• UNII: 3MVN4ORK1B
• DSSTox Substance ID: DTXSID10206935
• Nikkaji Number: J41.665G
• Mol file: 5819-93-2.mol

Synonyms:5819-93-2;METHANE, BIS-(o-METHOXYPHENYL)-;2,2'-Methylenebisanisole;Bis(o-methoxyphenyl)methane;Bis(2-methoxyphenyl)methane;Methane, bis(o-methoxyphenyl)-;NSC 78834;3MVN4ORK1B;BRN 2053995;Benzene, 1,1'-methylenebis(2-methoxy-;AI3-18957;NSC-78834;Benzene, 1,1'-methylenebis[2-methoxy-;NSC78834;UNII-3MVN4ORK1B;NCIOpen2_004371;WLN: 1OR B1R BO1;SCHEMBL3296809;DTXSID10206935;Benzene,1'-methylenebis[2-methoxy-;LS-89989;1,1'-METHYLENEBIS(2-METHOXYBENZENE)

Chemical Property of METHANE, BIS-(o-METHOXYPHENYL)-

Chemical Property:

• Boiling Point: 322.9oC at 760 mmHg
• Flash Point: 122.3oC
• PSA: 18.46000
• Density: 1.052g/cm3
• LogP: 3.29460
• XLogP3: 3.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 228.115029749
• Heavy Atom Count: 17
• Complexity: 195

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC=CC=C1CC2=CC=CC=C2OC

Technology Process of METHANE, BIS-(o-METHOXYPHENYL)-

There total 16 articles about METHANE, BIS-(o-METHOXYPHENYL)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

2-bromoanisole (578-57-4) + 4,4,5,5-tetramethyl-2-[(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl]-1,3,2-dioxaborolane (78782-17-9) → 2,2'-dimethoxydiphenylmethane (5819-93-2)

Guidance literature:

2-bromoanisole; 4,4,5,5-tetramethyl-2-[(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl]-1,3,2-dioxaborolane; With bis(tri-t-butylphosphine)palladium⁽⁰⁾; potassium hydroxide; In 1,4-dioxane; water; at 20 ℃; for 12h; Inert atmosphere;

With potassium hydroxide; In 1,4-dioxane; water; at 60 ℃; for 3h; Inert atmosphere;

DOI:10.1021/jo3015165

Reference yield: 28.0%

methoxybenzene (100-66-3) + 2-methoxyacetic acid (625-45-6) → carbon monoxide (201230-82-2) + 2-methoxy-1-(4-methoxy-phenyl)-ethanone (21160-26-9) + 1,1,2,2-tetrakis(4-methoxyphenyl)ethane (51048-43-2) + 4,4'-dianisylmethane (726-18-1) + 2,2'-dimethoxydiphenylmethane (5819-93-2) + 2,4'-dimethoxydiphenylmethane (30567-87-4)

Guidance literature:

With methanesulfonic acid; phosphorus pentoxide; for 24h; Product distribution; Ambient temperature;

DOI:10.1016/S0040-4020(97)00996-4

Reference yield:

salicylic alcohol (90-01-7) + (2-methoxyphenyl)methanol (612-16-8) + isopropyl alcohol (67-63-0,8013-70-5) → Bis(2-hydroxyphenyl)methane (2467-02-9) + 2-[(isopropyloxy)methyl]phenol (33316-78-8) + 2-[(4-hydroxyphenyl)methyl]phenol (2467-03-0) + 2,2'-dimethoxydiphenylmethane (5819-93-2) + 2,4'-dimethoxydiphenylmethane (30567-87-4) + o-(2-propoxymethyl)anisole

Guidance literature:

at 201.85 ℃; for 1h; Rate constant;

DOI:10.1021/jo981110f

upstream raw materials:

2,2'-dimethoxybenzophenone

Bis(2-hydroxyphenyl)methane

dimethyl sulfate

methyl iodide

Downstream raw materials:

Bis<2-Methoxy-5-(β-dimethylamino-ethyl)-phenyl>methan

Bis(2-methoxy-5-carboxyphenyl)methane

N,N-Dimethylamide of Bis(2-methoxy-5-carboxymethylphenyl)methane

Bis(2-methoxy-5-dimethylcarbamoylphenyl)methane