DIMETHYLCHLOROPHOSPHITE

Base Information

• Chemical Name: DIMETHYLCHLOROPHOSPHITE
• CAS No.: 3743-07-5
• Molecular Formula: C2H6 Cl O2 P
• Molecular Weight: 128.495
• Hs Code.: 2931900090
• Mol file: 3743-07-5.mol

Synonyms:Methylphosphorochloridite (6CI,7CI); Chlorodimethoxyphosphine;Dimethoxychlorophosphine; Dimethyl chlorophosphite; Dimethylphosphorochloridite

Chemical Property of DIMETHYLCHLOROPHOSPHITE

Chemical Property:

• Vapor Pressure: 50.8mmHg at 25°C
• Boiling Point: 96°Cat760mmHg
• Flash Point: 11.8°C
• PSA: 32.05000
• Density: g/cm³
• LogP: 1.74490

Purity/Quality:

98% ^*data from raw suppliers

DimethylChlorophosphite ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Dimethyl Chlorophosphite is a reagent used in the synthesis of 2-alkyl-3-phosphonopropanoic acid derivatives. Also used in the preparation of pyrimidine nucleoside phosphonic acids in the inhibition of human thymidine.

Technology Process of DIMETHYLCHLOROPHOSPHITE

There total 2 articles about DIMETHYLCHLOROPHOSPHITE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tetrachloromethane (56-23-5) + methyl phosphite (96-36-6,868-85-9) → chloroform (67-66-3,8013-54-5) + dimethyl chlorophosphite (3743-07-5)

Guidance literature:

With triethylamine; In cyclohexene; for 2h; Product distribution; Mechanism; Ambient temperature; oth. base, oth. solvent;

DOI:10.1246/bcsj.58.3671

Reference yield:

phosphorous acid trimethyl ester (121-45-9) → methyl dichlorophosphite (3279-26-3) + dimethyl chlorophosphite (3743-07-5)

Guidance literature:

With dichlorotriphenylphosphorane; In dichloromethane; Yield given. Yields of byproduct given; 1.) 1 h, r.t.; 2.) reflux, 3 h;

Reference yield: 76.0%

dimethyl chlorophosphite (3743-07-5) → methyl dichlorophosphite (3279-26-3) + Phosphorous acid trimethyl ester; compound with GENERIC INORGANIC NEUTRAL COMPONENT

Guidance literature:

With tin(IV) chloride; In pentane; at 0 ℃; for 72h; Product distribution; 0ther time, other temperature;

upstream raw materials:

tetrachloromethane

methyl phosphite

phosphorous acid trimethyl ester

Downstream raw materials:

diethyl ether

phosphorous acid dimethyl ester-(4-nitro-phenyl ester)

dimethyl thiophosphite

dimethoxy(dimethylamino)phosphine

Refernces

• 1、 Majewski, Piotr. "THE PREPARATION OF DIMETHYL PHOSPHOROCHLORIDITE AND ITS HOMOLOGS FROM TRIALKYL PHOSPHITES AND DICHLOROTRIPHENYLPHOSPHORANE". . p. 37 - 40. Retrieved 2007/10/02.