2 4-DICHLOROPENTANE

Base Information

• Chemical Name: 2 4-DICHLOROPENTANE
• CAS No.: 625-67-2
• Molecular Formula: C5H10Cl2
• Molecular Weight: 141.04
• Mol file: 625-67-2.mol

Synonyms:Meso-2,4-Dichloropentane;

Chemical Property of 2 4-DICHLOROPENTANE

Chemical Property:

• Vapor Pressure: 5.34mmHg at 25°C
• Melting Point: -75.05°C (estimate)
• Refractive Index: 1.43
• Boiling Point: 148.5 °C at 760 mmHg
• Flash Point: 36.5 °C
• PSA: 0.00000
• Density: 1.047 g/cm³
• LogP: 2.63110

Purity/Quality:

98%Min ^*data from raw suppliers

2 4-DICHLOROPENTANE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2 4-DICHLOROPENTANE

There total 5 articles about 2 4-DICHLOROPENTANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

DL-pentan-2,4-diol (1825-14-5) → (2R*,4R*)-2,4-dichloropentane (625-67-2,1625-67-8,1825-09-8)

Guidance literature:

With tetrachloromethane; triphenylphosphine; In acetonitrile; at 20 ℃; for 5h;

DOI:10.1002/(sici)1099-0690(199911)1999:11<2915::aid-ejoc2915>3.0.co;2-r

Reference yield:

hydrogenchloride (7647-01-0,15364-23-5) + aluminium trichloride (7446-70-0) + 2,3-dichloropentane (600-11-3) → 1,3-dichloro-3-methylbutane (624-96-4) + 2,4-dichloropentane (625-67-2)

Guidance literature:

at 30 ℃; unter Druck;

Reference yield:

2-methyl-1-chlorobutane (625-29-6) + chlorine (7782-50-5) → 2,4-dichloropentane (625-67-2) + 1,4-dichloropentane (626-92-6) + 2,3-dichloropentane (600-11-3)

Guidance literature:

beim Chlorieren entstehen noch geringe Menge 1.2- und 2.2-Dichlor-pentan;

upstream raw materials:

Pent-4-en-2-ol

hydrogenchloride

aluminium trichloride

2,3-dichloropentane

Downstream raw materials:

(-)-(2R,4R)-2,4-diphenylpentane

meso-2,4-diphenylpentane

racemic-2,4-diphenylpentane

Refernces

Rational design of novel, potent piperazinone and imidazolidinone BACE1 inhibitors

10.1016/j.bmcl.2008.04.050

The study presents the rational design and synthesis of novel piperazinone and imidazolidinone inhibitors targeting BACE1, an enzyme implicated in Alzheimer's disease (AD) due to its role in producing β-amyloid peptides, which are toxic to neurons. The researchers aimed to develop potent inhibitors that could potentially slow or halt the progression of AD. The key chemicals used in the study include piperazinones and imidazolidinones, which were designed to interact with both the flap and the S20 pocket of BACE1. These cyclic amine motifs were specifically crafted to achieve both occupancy of the S2 subsite and formation of an additional hydrogen bond to the flap, enhancing the inhibitors' potency. The study involved extensive structure-activity relationship (SAR) analysis around these compounds to optimize their binding affinity and selectivity. The purpose of these chemicals was to serve as therapeutic agents that could reduce BACE1 activity, thereby decreasing AD-like pathology in transgenic mouse models.