Bioorganic and Medicinal Chemistry Letters p. 3236 - 3241 (2008)
Update date:2022-09-26
Topics:
Cumming
Le
Babu
Carroll
Chen
Favreau
Gaspari
Guo
Hobbs
Huang
Iserloh
Kennedy
Kuvelkar
Li
Lowrie
McHugh
Ozgur
Pan
Parker
Saionz
Stamford
Strickland
Tadesse
Voigt
Wang
Wu
Zhang
Zhang
Guided by structure-based design, we synthesized two novel series of potent inhibitors of BACE1 and generated extensive SAR around both the prime and non-prime side binding pockets. The key feature of both series is a cyclic amine motif specifically crafted to achieve interactions with both the flap and with the S2′ pocket.
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