2-BROMO-NAPHTHALEN-1-OL

Base Information

• Chemical Name: 2-BROMO-NAPHTHALEN-1-OL
• CAS No.: 771-15-3
• Molecular Formula: C10H7BrO
• Molecular Weight: 223.069
• Hs Code.: 2908199090
• Mol file: 771-15-3.mol

Synonyms:2-Bromo-1-hydroxynaphthalene;2-Bromonaphthalen-1-ol;2-Bromo-1-naphthalenol;

Chemical Property of 2-BROMO-NAPHTHALEN-1-OL

Chemical Property:

• Vapor Pressure: 0.000264mmHg at 25°C
• Melting Point: 44-46℃
• Refractive Index: 1.704
• Boiling Point: 313.731 °C at 760 mmHg
• PKA: 7.25±0.50(Predicted)
• Flash Point: 143.539 °C
• PSA: 20.23000
• Density: 1.615 g/cm³
• LogP: 3.30790
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

2-Bromonaphthalen-1-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BROMO-NAPHTHALEN-1-OL

There total 5 articles about 2-BROMO-NAPHTHALEN-1-OL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

α-naphthol (90-15-3) → 4-bromo-1-naphthol (571-57-3) + 2,4-dibromo-1-naphthol (2050-49-9) + 2-bromo-1-naphthol (771-15-3)

Guidance literature:

With 4-(tribromomethyl)quinazoline; trifluoroacetic acid; In benzene; Heating;

Reference yield: 52.0%

α-naphthol (90-15-3) → 4-bromo-1-naphthol (571-57-3) + 2-bromo-1-naphthol (771-15-3)

Guidance literature:

With N-Bromosuccinimide; In acetonitrile; for 1h; Ambient temperature;

DOI:10.1055/s-1997-1553

Reference yield: 3.2%

2-bromonaphthalene (580-13-2) → 3-bromo-1-hydroxynaphthalene (90767-17-2) + 2-bromo-1-naphthol (771-15-3)

Guidance literature:

With tetrakis(pentafluorophenyl)porphyrin manganese(III) chloride; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; acetonitrile; at 27 ℃; for 1h; regioselective reaction; Inert atmosphere;

DOI:10.1002/poc.3012

upstream raw materials:

t-butyl bromide

α-naphthol

2,2-dibromo-1,2,3,4-tetrahydronaphthalen-1-one

2-bromonaphthalene

Downstream raw materials:

C₁₇H₁₃BrO₃S

Refernces

• 1、 Ding, Zhensheng,Xue, Song,Wulff, William D.. "A succinct synthesis of the vaulted biaryl ligand vanol via a dienone-phenol rearrangement". experimental part. p. 2130 - 2146. Retrieved 2011/10/18.
• 2、 Carre?o, M. Carmen,García Ruano, José L.,Sanz, Gema,Toledo, Miguel A.,Urbano, Antonio. "N-Bromosuccinimide as a Regioselective Nuclear Monobrominating Reagent for Phenols and Naphthols". . p. 1241 - 1242. Retrieved 2007/10/03.