5,8,14,17-Tetraoxa-2,11-diazanonadecanedioic acid, 10-oxo-, 1-(9H-fluoren-9-ylmethyl) ester

Base Information

• Chemical Name: 5,8,14,17-Tetraoxa-2,11-diazanonadecanedioic acid, 10-oxo-, 1-(9H-fluoren-9-ylmethyl) ester
• CAS No.: 560088-89-3
• Molecular Formula: C27H34N2O9

Synonyms:

Chemical Property of 5,8,14,17-Tetraoxa-2,11-diazanonadecanedioic acid, 10-oxo-, 1-(9H-fluoren-9-ylmethyl) ester

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5,8,14,17-Tetraoxa-2,11-diazanonadecanedioic acid, 10-oxo-, 1-(9H-fluoren-9-ylmethyl) ester

There total 1 articles about 5,8,14,17-Tetraoxa-2,11-diazanonadecanedioic acid, 10-oxo-, 1-(9H-fluoren-9-ylmethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

8-(9-fluorenylmethyloxycarbonyl-amino)-3,6-dioxaoctanoic acid (166108-71-0,675606-79-8) → 2-[2-[2-[[2-[2-[2-(9H-fluoren-9-ylmethoxycarbonyl-amino)ethoxy]ethoxy]acetyl]amino]ethoxy]ethoxy]acetic acid (560088-89-3)

Guidance literature:

8-(9-fluorenylmethyloxycarbonyl-amino)-3,6-dioxaoctanoic acid; With N-ethyl-N,N-diisopropylamine; In dichloromethane;

With piperidine; In N,N-dimethyl-formamide;

8-(9-fluorenylmethyloxycarbonyl-amino)-3,6-dioxaoctanoic acid; Further stages;

DOI:10.1038/s41429-018-0138-8

Reference yield:

3-methylbutyric acid (503-74-2) + Fmoc-Val-OH (68858-20-8) + Fmoc-Leu-OH (35661-60-0) + 1,18-octadecanedioic acid mono-tert-butyl ester (843666-40-0) + N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine (35661-39-3,136132-75-7) + 2-[2-[2-[[2-[2-[2-(9H-fluoren-9-ylmethoxycarbonyl-amino)ethoxy]ethoxy]acetyl]amino]ethoxy]ethoxy]acetic acid (560088-89-3) + Fmoc-Glu-OtBu (84793-07-7) + Fmoc-Pro-OH (71989-31-6) + Fmoc-Ser(tBu)-OH (71989-33-8) + Fmoc-Glu(OtBu)-OH (71989-18-9) + Fmoc-Tyr(tBu)-OH (71989-38-3,118488-18-9,204384-67-8) + Fmoc-Thr(tBu)-OH (71989-35-0,138797-71-4) + L-Asn(Trt) (132388-59-1) + Fmoc-L-Gln(Trt)-OH (132327-80-1,200623-62-7) + Fmoc-Lys(Dde)-OH (150629-67-7) + trifluoroacetic acid (76-05-1) + 3-[(S)-2-carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]indole-1-carboxylic acid tert-butyl ester (143824-78-6,163619-04-3) + Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine (187618-60-6) → N{α-4}-(3-methylbutanoyl)-N{ε-7}-[2-(2-{2-[2-(2-{2-[(4S)-4-carboxy-4-(17-carboxyheptadecanamido)butanamido]ethoxy}ethoxy)acetamido]-ethoxy}ethoxy)acetamido]-[4A,7K,9E,11E,18Q,22V,26A,28Y,30W,31L]hPYY(4-36) trifluoroacetate

Guidance literature:

Fmoc-Tyr(tBu)-OH; With ethyl cyanoglyoxylate-2-oxime; diisopropyl-carbodiimide; In N,N-dimethyl-formamide; at 75 ℃; for 0.0833333h; Automated synthesizer;

With piperidine; In N,N-dimethyl-formamide; at 75 ℃; for 0.0583333h; Automated synthesizer;

3-methylbutyric acid; Fmoc-Val-OH; Fmoc-Leu-OH; 1,18-octadecanedioic acid mono-tert-butyl ester; N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine; 2-[2-[2-[[2-[2-[2-(9H-fluoren-9-ylmethoxycarbonyl-amino)ethoxy]ethoxy]acetyl]amino]ethoxy]ethoxy]acetic acid; Fmoc-Glu-OtBu; Fmoc-Pro-OH; Fmoc-Ser(tBu)-OH; Fmoc-Glu(OtBu)-OH; Fmoc-Thr(tBu)-OH; L-Asn(Trt); Fmoc-L-Gln(Trt)-OH; Fmoc-Lys(Dde)-OH; trifluoroacetic acid; 3-[(S)-2-carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]indole-1-carboxylic acid tert-butyl ester; Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine; Further stages;

Reference yield:

3-methylbutyric acid (503-74-2) + Fmoc-Val-OH (68858-20-8) + Fmoc-Leu-OH (35661-60-0) + 1,18-octadecanedioic acid mono-tert-butyl ester (843666-40-0) + N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine (35661-39-3,136132-75-7) + 2-[2-[2-[[2-[2-[2-(9H-fluoren-9-ylmethoxycarbonyl-amino)ethoxy]ethoxy]acetyl]amino]ethoxy]ethoxy]acetic acid (560088-89-3) + Fmoc-Glu-OtBu (84793-07-7) + Fmoc-Pro-OH (71989-31-6) + Fmoc-Ser(tBu)-OH (71989-33-8) + Fmoc-(tBu)Asp-OH (71989-14-5) + Fmoc-Glu(OtBu)-OH (71989-18-9) + Fmoc-Tyr(tBu)-OH (71989-38-3,118488-18-9,204384-67-8) + Fmoc-Thr(tBu)-OH (71989-35-0,138797-71-4) + L-Asn(Trt) (132388-59-1) + Fmoc-L-Gln(Trt)-OH (132327-80-1,200623-62-7) + Fmoc-His(Trt)-OH (109425-51-6) + Fmoc-Lys(Dde)-OH (150629-67-7) + trifluoroacetic acid (76-05-1) + 3-[(S)-2-carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]indole-1-carboxylic acid tert-butyl ester (143824-78-6,163619-04-3) + Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine (187618-60-6) → N{α-4}-(3-methylbutanoyl)-N{ε-7}-[2-(2-{2-[2-(2-{2-[(4S)-4-carboxy-4-(17-carboxyheptadecanamido)butanamido]ethoxy}ethoxy)acetamido]-ethoxy}ethoxy)acetamido]-[4A,7K,9E,14E,18Q,19Q,22V,28Y,30W,31L]hPYY(4-36) trifluoroacetate

Guidance literature:

Fmoc-Tyr(tBu)-OH; With ethyl cyanoglyoxylate-2-oxime; diisopropyl-carbodiimide; In N,N-dimethyl-formamide; at 20 ℃; for 2h; Automated synthesizer;

With piperidine; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 0.3h; Automated synthesizer;

3-methylbutyric acid; Fmoc-Val-OH; Fmoc-Leu-OH; 1,18-octadecanedioic acid mono-tert-butyl ester; N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine; 2-[2-[2-[[2-[2-[2-(9H-fluoren-9-ylmethoxycarbonyl-amino)ethoxy]ethoxy]acetyl]amino]ethoxy]ethoxy]acetic acid; Fmoc-Glu-OtBu; Fmoc-Pro-OH; Fmoc-Ser(tBu)-OH; Fmoc-(tBu)Asp-OH; Fmoc-Glu(OtBu)-OH; Fmoc-Thr(tBu)-OH; L-Asn(Trt); Fmoc-L-Gln(Trt)-OH; Fmoc-His(Trt)-OH; Fmoc-Lys(Dde)-OH; trifluoroacetic acid; 3-[(S)-2-carboxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)ethyl]indole-1-carboxylic acid tert-butyl ester; Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine; Further stages;

upstream raw materials:

8-(9-fluorenylmethyloxycarbonyl-amino)-3,6-dioxaoctanoic acid

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